Bronchopulmonary dysplasia in neonates born to mothers with preeclampsia: Impact of small for gestational age

• Published in: PloS one Vol. 13; no. 9; p. e0204498
• Main Authors: Dravet-Gounot, Pauline, Torchin, Héloïse, Goffinet, François, Aubelle, Marie-Stéphanie, El Ayoubi, Mayass, Lefevre, Claire, Jarreau, Pierre-Henri, Zana-Taïeb, Elodie
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 24.09.2018; Public Library of Science (PLoS)
• Subjects: Age; Analysis; Biology and Life Sciences; Birth weight; Blood pressure; Bronchopulmonary dysplasia; Cohort analysis; Complications and side effects; Confidence intervals; Development and progression; Dysplasia; Gestation; Gestational age; Health aspects; Health risk assessment; Hypertension; Low birth weight; Lung diseases; Medicine and Health Sciences; Neonates; Newborn babies; Pediatrics; People and Places; Pre-eclampsia; Preeclampsia; Pregnancy; Premature birth; Premature infants; Regression analysis; Regression models; Research and Analysis Methods; Risk analysis; Risk factors; Small for gestational age; Statistical analysis; Veins & arteries; Weight; France; Asia
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0204498

Small for gestational age and preeclampsia have both been described as risk factors for bronchopulmonary dysplasia in preterm neonates, but their respective role in the occurrence of bronchopulmonary dysplasia is debated. We evaluated the relation between small for gestational age and bronchopulmonary dysplasia in neonates born to mothers with preeclampsia. We hypothesized that low birth weight is still associated with bronchopulmonary dysplasia in this homogeneous population. Retrospective single-center cohort study including 141 neonates born between 24 and 30 weeks' gestation to mothers with preeclampsia. The main outcome measure was moderate to severe bronchopulmonary dysplasia at 36 weeks' postmenstrual age. Neonates born small for gestational age (birthweight < 10th percentile on the AUDIPOG curves) were compared to those with appropriate birthweight for gestational age by bivariable analyses and logistic regression models, estimating odds ratios (ORs) and 95% confidence intervals (CIs). Bronchopulmonary dysplasia rates were 61.5% (32/52) and 27.4% (20/73) for small for gestational age and appropriate birthweight for gestational age neonates (p < .001). On adjustment for gestational age and other confounding factors, the risk of moderate to severe bronchopulmonary dysplasia was greater for small for gestational age than appropriate birthweight for gestational age neonates (adjusted OR = 5.9, 95% CI [2.2-15.4]), as was the composite outcome death or moderate to severe bronchopulmonary dysplasia (adjusted OR = 4.7, 95% CI [1.9-11.3]). Small for gestational age was associated with bronchopulmonary dysplasia in very preterm neonates born to mothers with preeclampsia. CNIL no. 1747084.