Relationship between HbA1c, fructosamine and clinical assessment of glycemic control in dogs

• Published in: PloS one Vol. 17; no. 2; p. e0264275
• Main Authors: Norris, Olga, Schermerhorn, Thomas
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.02.2022; Public Library of Science (PLoS)
• Subjects: Analysis; Animals; Automation; Biology and Life Sciences; Classification; Comparative analysis; Diabetes; Diabetes mellitus; Diabetes Mellitus - blood; Diabetes Mellitus - veterinary; Disease control; Dog Diseases - blood; Dogs; Female; Fructosamine - blood; Fructose; Glucose; Glycated Hemoglobin A - metabolism; Glycemic Control; Glycosylated hemoglobin; Health aspects; Hemoglobin; Immunoassay; Laboratories; Male; Medicine and health sciences; Monitoring; Physical Sciences; Population; Proteins; Standard deviation; Veterinary colleges; Veterinary medicine; United States; United States > US; Kansas
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0264275

Serum fructosamine is a routine test used for clinical monitoring of diabetes mellitus (DM) but the usefulness of HbA1c for this purpose has not been extensively studied. The study aimed to compare the ability of blood HbA1c and serum fructosamine tests to correctly classify DM control determined using a clinically-based assessment. 28 client-owned dogs with naturally-occurring diabetes mellitus. Cross-sectional observational study. Ability of fructosamine and HbA1c tests to classify diabetes control in dogs was determined. Clinical assessment classified 50% of dogs as having good diabetic control and 82% as having acceptable diabetic control. Analysis using Cohen's kappa test showed that agreements between fructosamine and HbA1c results and the clinical assessment ranged from poor to fair. Fructosamine and HbA1c results from each dog showed a moderate correlation. Overall, the HbA1c test showed the best agreement with the clinical assessment when diabetes control was considered either acceptable or unacceptable, although the strength of agreement was considered fair (kappa = 0.27). The HbA1c concentration was found to be more consistent with clinical evaluation of diabetes control than was the serum fructosamine concentration. The HbA1c level is a useful tool for assessment of glycemic status in diabetic dogs but should be used alongside other tests for outpatient monitoring of clinically stable diabetic dogs.