Local autoimmune encephalomyelitis model in a rat brain with precise control over lesion placement

• Published in: PloS one Vol. 17; no. 1; p. e0262677
• Main Authors: Kalkowski, Lukasz, Golubczyk, Dominika, Kwiatkowska, Joanna, Domzalska, Malgorzata, Walczak, Piotr, Malysz-Cymborska, Izabela
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.01.2022; Public Library of Science (PLoS)
• Subjects: Analysis; Animal models; Animals; Antibodies; Antibodies - immunology; Autoimmunity; Biology and Life Sciences; Blood-brain barrier; Brain - pathology; Brain research; Care and treatment; Cattle; Demyelination; Diagnosis; Encephalomyelitis; Encephalomyelitis, Autoimmune, Experimental - etiology; Encephalomyelitis, Autoimmune, Experimental - pathology; Epitopes; Experimental allergic encephalomyelitis; Growth factors; Histology; Immunization; Injection; Injections, Intraventricular; Lesions; Male; Medicine; Medicine and Health Sciences; Morbidity; Multiple sclerosis; Myelin; Neurological complications; Neurosurgery; Placement; Rats; Rats, Wistar; Reproducibility; Spinal cord; Spinal Cord - immunology; Vascular endothelial growth factor; Video recorders; Poland

Development of a novel, animal model for multiple sclerosis (MS) with reproducible and predictable lesion placement would enhance the discovery of effective treatments. Therefore, we would like to combine the advantages of the demyelination model with experimental autoimmune encephalomyelitis (EAE)...