Choroidal thickness in normal Indian subjects using Swept source optical coherence tomography

• Published in: PloS one Vol. 13; no. 5; p. e0197457
• Main Authors: Akhtar, Zeeshan, Rishi, Pukhraj, Srikanth, Ramasubramanian, Rishi, Ekta, Bhende, Muna, Raman, Rajiv
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.05.2018; Public Library of Science (PLoS)
• Subjects: Age; Biology and Life Sciences; Blood pressure; Correlation; Diabetes; Diagnosis; Eye; Eye (anatomy); Eye diseases; Fovea; Laboratories; Macular degeneration; Medical imaging; Medicine and Health Sciences; Optical Coherence Tomography; People and Places; Perfusion; Quadrants; Research and Analysis Methods; Retina; Risk factors; Tomography; Variance analysis; India; United States > US
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0197457

To determine choroidal thickness in healthy Indian subjects using Swept source optical coherence tomography (SS-OCT). In this prospective, observational, cross-sectional study; healthy Indian subjects (n = 230) with no history of ocular and/or systemic disorders were enrolled in the study. Choroidal thickness was measured for 230 eyes using SS-OCT. Subjects were divided into six age groups. Main outcome measures were subfoveal choroidal thickness (SFCT) and macular choroidal thickness (MCT) up to 3 mm at 500-micron interval from the fovea was measured in eight different quadrants. The mean SFCT was 307±79 μm and mean MCT was 285±75 μm. No difference in the choroidal thickness was found among genders. Mean SFCT of the different age groups was 327±68 μm (12-18 years), 364±70 μm (18.1-30 years), 321±78 μm (30.1-40 years), 304±79 μm (40.1-50 years), 283±69 μm (50.1-60 years) and 262±72μm (above 60 years; p <0.001; One way ANOVA). Mean macular choroidal thickness was 305±60 μm, 342±61 μm, 306±72 μm, 282±79 μm, 261±66 μm, 238±68μm respectively (p<0.001; one way ANOVA). A significant weak negative correlation was found between age with SFCT (r = -0.368, p<0.001) and MCT (r = -0.40, p<0.001). No significant correlation was found with refractive error, axial length and ocular perfusion pressure. This study showed that mean SFCT and MCT was 307±79μm and 285±75 μm, respectively, among healthy Indian subjects. Mean CT was found to decrease with age, although there was no difference in CT between genders.