Assessment of transposition of the great arteries associated with multiple malformations using dual-source computed tomography

• Published in: PloS one Vol. 12; no. 11; p. e0187578
• Main Authors: Xie, Lin-Jun, Jiang, Li, Yang, Zhi-Gang, Shi, Ke, Xu, Hua-Yan, Li, Rui, Diao, Kai-Yue, Guo, Ying-Kun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 20.11.2017; Public Library of Science (PLoS)
• Subjects: Abnormalities; Angiography; Anomalies; Aorta; Arteries; Biology and Life Sciences; Birth defects; Blood vessels; Cardiology; Cardiovascular disease; Computation; Computed tomography; Congenital diseases; Coronary artery; Coronary vessels; CT imaging; Decision making; Diagnosis; Diagnostic systems; Echocardiography; Heart; Hospitals; Laboratories; Mathematical analysis; Medical imaging; Medicine and Health Sciences; Morphology; Obstetrics; Patients; Pediatrics; Physical characteristics; Pulmonary arteries; Pulmonary artery; Stenosis; Surgery; Transposition; Transposition of great arteries; Veins & arteries; Ventricle; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0187578

To determine the value of dual-source computed tomography (DSCT) in depicting the morphological characteristics and diagnosing the associated malformations for patients with transposition of the great arteries (TGA) before surgery. Twenty-five patients with TGA who underwent DSCT and transthoracic echocardiography (TTE) examination were retrospectively reviewed. The morphological types of TGA, the spatial relationship between the pulmonary artery and the aorta, as well as coronary artery-associated abnormalities were assessed by DSCT. In contrast to TTE, the diagnostic accuracy of associated malformations on DSCT were analyzed and calculated with reference to surgical or digital subtraction angiography (DSA) findings. Effective doses (EDs) were also calculated. Among the 25 patients, 12 (48%) had ventricular septal defects and left ventricular outflow tract stenosis. Sixteen patients (16/25, 64%) had great arteries with an oblique spatial relationship on DSCT. In addition, we found seven patients (7/25, 28%) with coronary artery malformation, including five with an abnormal coronary origin and two with signs of a myocardial bridge. According to DSA or surgical findings, DSCT was superior to TTE in demonstrating extracardiac anomalies (sensitivity, anomalies of great vessels: 100% vs. 93.33%, other anomalies: 100% vs. 46.15%). The mean estimated ED for those aged <10 years was <2 mSv (1.59 ± 0.95 mSv). DSCT can achieve an overall assessment of patients with TGA, including any associated malformations as well as the identification of the spatial relationship of the great arteries. DSCT can therefore be considered as an alternative imaging modality for surgical decision making.