Maternal Obesity Affects Fetal Neurodevelopmental and Metabolic Gene Expression: A Pilot Study

• Published in: PloS one Vol. 9; no. 2; p. e88661
• Main Authors: Edlow, Andrea G., Vora, Neeta L., Hui, Lisa, Wick, Heather C., Cowan, Janet M., Bianchi, Diana W.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.02.2014; Public Library of Science (PLoS)
• Subjects: Abnormalities; Acids; Adult; Age; Amniocentesis; Amniotic fluid; Analysis; Apolipoproteins; Apoptosis; Biology; Body mass; Body mass index; Cell death; Central nervous system; Cerebral cortex; Cerebrum; Computational Biology; Epigenetics; Estrogens; Female; Fetus - embryology; Fetus - metabolism; Fetuses; Fos protein; Gene expression; Gene Expression Regulation, Developmental; Genes; Genomes; Genomics; Gestational age; Gynecology; Humans; Hybridization; Inflammation; Karyotypes; Laboratories; Medicine; Metabolic syndrome; Middle Aged; Molecular modelling; Morbidity; Mothers; Nervous System - embryology; Neurodevelopmental disorders; Obesity; Obstetrics; Offspring; Oligonucleotide Array Sequence Analysis; Organ Specificity; Pilot Projects; Pregnancy; Pregnancy Trimester, Second; Pregnant women; Regulators; Ribonucleic acid; RNA; Rodents; Signal transduction; Stat3 protein; Studies; Transcription activation; Womens health; Xenoestrogens; Young Adult; United States > US; Massachusetts

One in three pregnant women in the United States is obese. Their offspring are at increased risk for neurodevelopmental and metabolic morbidity. Underlying molecular mechanisms are poorly understood. We performed a global gene expression analysis of mid-trimester amniotic fluid cell-free fetal RNA i...