The facilitating role of chemotherapy in the palliative phase of cancer: qualitative interviews with advanced cancer patients

• Published in: PloS one Vol. 8; no. 11; p. e77959
• Main Authors: Buiting, Hilde M, Terpstra, Wim, Dalhuisen, Floriske, Gunnink-Boonstra, Nicolette, Sonke, Gabe S, den Hartogh, Govert
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.11.2013; Public Library of Science (PLoS)
• Subjects: Advance directives; Aged; Aged, 80 and over; Analysis; Anxiety; Attitude to Death; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - mortality; Breast Neoplasms - pathology; Cancer; Cancer patients; Cancer therapies; Care and treatment; Chemotherapy; Colorectal cancer; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; Communication; Content analysis; Evidence-based medicine; Female; Hospitals; Humans; Internal medicine; Interviews; Interviews as Topic; Lung cancer; Male; Medical personnel; Medical prognosis; Metastasis; Middle Aged; Oncology; Palliation; Palliative Care; Patient Acceptance of Health Care; Patients; Physicians; Professional-Patient Relations; Side effects; Studies; Netherlands
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0077959

To explore the extent to which patients have a directing role in decisions about chemotherapy in the palliative phase of cancer and (want to) anticipate on the last stage of life. Qualitative interview study. In depth-interviews with 15 patients with advanced colorectal or breast cancer at the medical oncology department in a Dutch teaching hospital; interviews were analysed following the principles of thematic content-analysis. All patients reported to know that the chemotherapy they received was with palliative intent. Most of them did not express the wish for information about (other) treatment options and put great trust in their physicians' treatment advice. The more patients were aware of the severity of their disease, the more they seemed to 'live their life' in the present and enjoy things besides having cancer. Such living in the present seemed to be facilitated by the use of chemotherapy. Patients often considered the 'chemotherapy-free period' more stressful than periods when receiving chemotherapy despite their generally improved physical condition. Chemotherapy (regardless of side-effects) seemed to shift patients' attention away from the approaching last stage of life. Interestingly, although patients often discussed advance care planning, they were reluctant to bring on end-of-life issues that bothered them at that specific moment. Expressing real interest in people 'as a person' was considered an important element of appropriate care. Fearing their approaching death, patients deliberately focus on living in the present. Active (chemotherapy) treatment facilitates this focus, regardless of the perceived side-effects. However, if anxiety for what lies ahead is the underlying reason for treatment, efforts should be made in assisting patients to find other ways to cope with this fear. Simultaneously, such an approach may reduce the use of burdensome and sometimes costly treatment in the last stage of life.