Two New Quinoline and Tris(4-hydroxycinnamoyl)spermine Derivatives from Microdesmis keayana Roots

Purification of a Microdesmis keayana hydromethanolic root extract led to the isolation of two new natural compounds, xanthoquininamide (6-hydroxyquinoline-4-carboxamide) and tris(4-hydroxycinnamoyl)spermine (N5-(p-coumaroyl)-N1,N14-diferuloylspermine) which was named keayanine. Their structures wer...

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Bibliographic Details
Published inChemical & Pharmaceutical Bulletin Vol. 55; no. 4; pp. 643 - 645
Main Authors Zamble, Alexis, Hennebelle, Thierry, Sahpaz, Sevser, Bailleul, François
Format Journal Article
LanguageEnglish
Japanese
Published TOKYO The Pharmaceutical Society of Japan 01.04.2007
Pharmaceutical Society of Japan
Pharmaceutical Soc Japan
Japan Science and Technology Agency
Subjects
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
Coumaric Acids
Life Sciences & Biomedicine
Magnetic Resonance Spectroscopy
Microdesmis keayana
Pandaceae
Pharmacology & Pharmacy
Physical Sciences
Plant Roots - chemistry
Quinolines - isolation & purification
Science & Technology
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Spermine - analogs & derivatives
Spermine - isolation & purification
tris(4-hydroxycinnamoyl)spermine
xanthoquininamide
VITRO ANTIPLASMODIAL ACTIVITY
PLANTS
xanthoquininamide
Pandaceae
Microdesmis keayana
tris(4-hydroxycinnamoyl)spermine
CYTOTOXICITY
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Summary:Purification of a Microdesmis keayana hydromethanolic root extract led to the isolation of two new natural compounds, xanthoquininamide (6-hydroxyquinoline-4-carboxamide) and tris(4-hydroxycinnamoyl)spermine (N5-(p-coumaroyl)-N1,N14-diferuloylspermine) which was named keayanine. Their structures were determined using spectroscopic analyses (ESI-MS, 1D- and 2D-NMR).
Bibliography:ObjectType-Article-2
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ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.55.643