Myoelectric prosthesis hand grasp control following targeted muscle reinnervation in individuals with transradial amputation

• Published in: PloS one Vol. 18; no. 1; p. e0280210
• Main Authors: Simon, Ann M., Turner, Kristi L., Miller, Laura A., Dumanian, Gregory A., Potter, Benjamin K., Beachler, Mark D., Hargrove, Levi J., Kuiken, Todd A.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.01.2023; Public Library of Science (PLoS)
• Subjects: Activities of daily living; Amputation; Amputation, Surgical; Analysis; Artificial Limbs; Availability; Biology and Life Sciences; Care and treatment; Electrodes; Electromyography; Electromyography - methods; Engineering and Technology; Health aspects; Humans; Implants, Artificial; Limbs; Medical errors; Medicine and Health Sciences; Muscle contraction; Muscle, Skeletal - innervation; Muscles; Muscular function; Myoelectric control; Myoelectric prosthesis; Myoelectricity; Nerves; Pain; Patient outcomes; Pattern recognition; Pattern recognition systems; Phantom Limb; Prevention; Prostheses; Prosthesis; Reinnervation; Research and Analysis Methods; Smartphones; Surgery; Upper Extremity; United States
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0280210

Despite the growing availability of multifunctional prosthetic hands, users' control and overall functional abilities with these hands remain limited. The combination of pattern recognition control and targeted muscle reinnervation (TMR) surgery, an innovative technique where amputated nerves are transferred to reinnervate new muscle targets in the residual limb, has been used to improve prosthesis control of individuals with more proximal upper limb amputations (i.e., shoulder disarticulation and transhumeral amputation). The goal of this study was to determine if prosthesis hand grasp control improves following transradial TMR surgery. Eight participants were trained to use a multi-articulating hand prosthesis under myoelectric pattern recognition control. All participated in home usage trials pre- and post-TMR surgery. Upper limb outcome measures were collected following each home trial. Three outcome measures (Southampton Hand Assessment Procedure, Jebsen-Taylor Hand Function Test, and Box and Blocks Test) improved 9-12 months post-TMR surgery compared with pre-surgery measures. The Assessment of Capacity for Myoelectric Control and Activities Measure for Upper Limb Amputees outcome measures had no difference pre- and post-surgery. An offline electromyography analysis showed a decrease in grip classification error post-TMR surgery compared to pre-TMR surgery. Additionally, a majority of subjects noted qualitative improvements in their residual limb and phantom limb sensations post-TMR. The potential for TMR surgery to result in more repeatable muscle contractions, possibly due to the reduction in pain levels and/or changes to phantom limb sensations, may increase functional use of many of the clinically available dexterous prosthetic hands.