The association of common SNPs and haplotypes in CETP gene with HDL cholesterol levels in Latvian population

• Published in: PloS one Vol. 8; no. 5; p. e64191
• Main Authors: Radovica, Ilze, Fridmanis, Davids, Vaivade, Iveta, Nikitina-Zake, Liene, Klovins, Janis
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.05.2013; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Apolipoproteins; Biology; Blood cholesterol; Cardiovascular disease; CETP gene; Cholesterol; Cholesterol Ester Transfer Proteins - genetics; Cholesterol, HDL - blood; Cholesterol, HDL - genetics; Cholesterol, LDL - blood; Cholesterol, LDL - genetics; Databases, Genetic; Female; Gene expression; Gene loci; Gene regulation; Genes; Genetic aspects; Genome-wide association studies; Genome-Wide Association Study; Genomes; Genomics; Haplotypes; Heredity; Heritability; High density lipoprotein; Humans; Latvia; Lipids; Low density lipoprotein; Male; Medicine; Middle Aged; Polymorphism, Single Nucleotide; Population density; Risk Factors; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Latvia
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0064191

The heritability of high-density lipoprotein cholesterol (HDL-C) level is estimated at approximately 50%. Recent genome-wide association studies have identified genes involved in regulation of high-density lipoprotein cholesterol (HDL-C) levels. The precise genetic profile determining heritability of HDL-C however are far from complete and there is substantial room for further characterization of genetic profiles influencing blood lipid levels. Here we report an association study comparing the distribution of 139 SNPs from more than 30 genes between groups that represent extreme ends of HDL-C distribution. We genotyped 704 individuals that were selected from Genome Database of Latvian Population. 10 SNPs from CETP gene showed convincing association with low HDL-C levels (rs1800775, rs3764261, rs173539, rs9939224, rs711752, rs708272, rs7203984, rs7205804, rs11076175 and rs9929488) while 34 SNPs from 10 genes were nominally associated (p<0.05) with HDL-C levels. We have also identified haplotypes from CETP with distinct effects on determination of HDL-C levels. Our conclusion: So far the SNPs in CETP gene are identified as the most common genetic factor influencing HDL-C levels in the representative sample from Latvian population.