Modelling of thrombus formation using smoothed particle hydrodynamics method

• Published in: PloS one Vol. 18; no. 2; p. e0281424
• Main Authors: Monteleone, Alessandra, Viola, Alessia, Napoli, Enrico, Burriesci, Gaetano
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.02.2023; Public Library of Science (PLoS)
• Subjects: Biology and Life Sciences; Blood; Blood clot; Blood clots; Blood clotting; Blood Coagulation; Blood platelets; Cardiovascular research; Computer Simulation; Detention; Detention of persons; Development and progression; Dynamics of a particle; Enzymes; Fluid dynamics; Fluid mechanics; Fluid-structure interaction; Hemodynamics; Humans; Hydrodynamics; Hydrofoil boats; Medicine and Health Sciences; Methods; Modelling; Molecules; Physical Sciences; Physiology; Pulmonary embolisms; Shear stress; Smooth particle hydrodynamics; Solid phases; Thromboembolism; Thrombosis; Italy
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0281424

In this paper a novel model, based on the smoothed particle hydrodynamics (SPH) method, is proposed to simulate thrombus formation. This describes the main phases of the coagulative cascade through the balance of four biochemical species and three type of platelets. SPH particles can switch from fluid to solid phase when specific biochemical and physical conditions are satisfied. The interaction between blood and the forming blood clot is easily handled by an innovative monolithic FSI approach. Fluid-solid coupling is modelled by introducing elastic binds between solid particles, without requiring detention and management of the interface between the two media. The proposed model is able to realistically reproduce the thromboembolic process, as confirmed by the comparison of numerical results with experimental data available in the literature.