Towards an Elastographic Atlas of Brain Anatomy

• Published in: PloS one Vol. 8; no. 8; p. e71807
• Main Authors: Guo, Jing, Hirsch, Sebastian, Fehlner, Andreas, Papazoglou, Sebastian, Scheel, Michael, Braun, Juergen, Sack, Ingolf
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.08.2013; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Alzheimer's disease; Alzheimers disease; Anatomy; Biology; Brain; Brain - physiology; Brain mapping; Brain Mapping - methods; Caudate nucleus; Corpus callosum; Elasticity Imaging Techniques - methods; Female; Fractals; Head; Healthy Volunteers; Humans; Image detection; Magnetic resonance; Magnetic Resonance Imaging; Male; Mathematics; Medicine; Middle Aged; Multiple sclerosis; Nervous system diseases; Neurological diseases; NMR; Nuclear magnetic resonance; Oscillations; Shear modulus; Spatial discrimination; Spatial resolution; Stiffness; Substantia alba; Thalamus; Therapeutic applications; Viscoelasticity; Young Adult
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0071807

Cerebral viscoelastic constants can be measured in a noninvasive, image-based way by magnetic resonance elastography (MRE) for the detection of neurological disorders. However, MRE brain maps of viscoelastic constants are still limited by low spatial resolution. Here we introduce three-dimensional multifrequency MRE of the brain combined with a novel reconstruction algorithm based on a model-free multifrequency inversion for calculating spatially resolved viscoelastic parameter maps of the human brain corresponding to the dynamic range of shear oscillations between 30 and 60 Hz. Maps of two viscoelastic parameters, the magnitude and the phase angle of the complex shear modulus, |G*| and φ, were obtained and normalized to group templates of 23 healthy volunteers in the age range of 22 to 72 years. This atlas of the anatomy of brain mechanics reveals a significant contrast in the stiffness parameter |G*| between different anatomical regions such as white matter (WM; 1.252±0.260 kPa), the corpus callosum genu (CCG; 1.104±0.280 kPa), the thalamus (TH; 1.058±0.208 kPa) and the head of the caudate nucleus (HCN; 0.649±0.101 kPa). φ, which is sensitive to the lossy behavior of the tissue, was in the order of CCG (1.011±0.172), TH (1.037±0.173), CN (0.906±0.257) and WM (0.854±0.169). The proposed method provides the first normalized maps of brain viscoelasticity with anatomical details in subcortical regions and provides useful background data for clinical applications of cerebral MRE.