The Relationship of Metabolic Syndrome with Stress, Coronary Heart Disease and Pulmonary Function--An Occupational Cohort-Based Study

• Published in: PloS one Vol. 10; no. 8; p. e0133750
• Main Authors: Janczura, Miroslaw, Bochenek, Grazyna, Nowobilski, Roman, Dropinski, Jerzy, Kotula-Horowitz, Katarzyna, Laskowicz, Bartosz, Stanisz, Andrzej, Lelakowski, Jacek, Domagala, Teresa
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.08.2015; Public Library of Science (PLoS)
• Subjects: Adult; Angiography; Arteries; Arteriosclerosis; Atherosclerosis; Cardiovascular disease; Cardiovascular diseases; Carotid artery; Cohort Studies; Computed tomography; Coronary artery; Coronary artery disease; Coronary Artery Disease - epidemiology; Coronary Disease - epidemiology; Coronary heart disease; Coronary vessels; Diabetes; Diabetes mellitus; EKG; Electrocardiography; Exercise; Female; Health risks; Heart; Heart diseases; Hospitals; Humans; Insulin resistance; Internal medicine; Job stress; Low level; Lung diseases; Male; Medical research; Medicine; Metabolic syndrome; Metabolic Syndrome - epidemiology; Middle Aged; Mortality; Obesity; Occupational health; Older people; Parameters; Physical activity; Plaque, Atherosclerotic - epidemiology; Police; Population; Psychological stress; Public health; Pulmonary functions; Regression analysis; Respiratory function; Respiratory Function Tests; Risk analysis; Risk Factors; Risk perception; Stress, Physiological - physiology; Studies; Poland; United States > US
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0133750

Higher levels of stress impact the prevalence of metabolic syndrome (MetS) and coronary heart disease. The association between MetS, impaired pulmonary function and low level of physical activity is still pending assessment in the subjects exposed to stress. The study aimed to examine whether higher levels of stress might be related to MetS and the plaque presence, as well as whether MetS might affect pulmonary function. The study embraced 235 police officers (mean age 40.97 years) from the south of Poland. The anthropometrics and biochemical variables were measured; MetS was diagnosed using the International Diabetes Federation criteria. Computed tomography coronary angiography of coronary arteries, exercise ECG, measurements of brachial flow-mediated dilation, and carotid artery intima-media thickness were completed. In order to measure the self-perception of stress, 10-item Perceived Stress Scale (PSS-10) was applied. Pulmonary function and physical activity levels were also addressed. Multivariate logistic regression analyses were applied to determine the relationships between: 1/ incidence of coronary plaque and MetS per se, MetS components and the number of classical cardiovascular risk factors, 2/ perceived stress and MetS, 3/ MetS and pulmonary function parameters. Coronary artery atherosclerosis was less associated with MetS (OR = 2.62, 95%CI 1.24-5.52; p = 0.011) than with a co-existence of classical cardiovascular risk factors (OR = 5.67, 95% CI 1.07-29.85, p = 0.03; for 3 risk factors and OR = 9.05; 95% CI 1.24-66.23, p = 0.02; for 6 risk factors, respectively). Perceived stress increased MetS prevalence (OR = 1.07, 95% CI 1.03-1.13; p = 0.03), and impacted coronary plaque prevalence (OR = 1.05, 95% CI 1.001-1.10; p = 0.04). Leisure-time physical activity reduced the chances of developing MetS (OR = 0.98 95% CI 0.96-0.99; p = 0.02). MetS subjects had significantly lower values of certain pulmonary function parameters. Exposure to job-specific stress among police officers increased the prevalence of MetS and impacted coronary plaque presence. MetS subjects had worse pulmonary function parameters. Early-stage, comprehensive therapeutic intervention may reduce overall risk of cardiovascular events and prevent pulmonary function impairment in this specific occupational population.