Real-time 3T MRI-guided cardiovascular catheterization in a porcine model using a glass-fiber epoxy-based guidewire

• Published in: PloS one Vol. 15; no. 2; p. e0229711
• Main Authors: Li, Xinzhou, Perotti, Luigi E, Martinez, Jessica A, Duarte-Vogel, Sandra M, Ennis, Daniel B, Wu, Holden H
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.02.2020; Public Library of Science (PLoS)
• Subjects: Animal models; Bioengineering; Biology and Life Sciences; Catheterization; Catheters; Design; Electrocardiography; Engineering and Technology; Epoxy resins; Evaluation; Experiments; Feasibility; Fluoroscopy; Ghosts; Glass fiber reinforced plastics; Glass-epoxy composites; Heating; Intubation; Laboratory animals; Magnetic resonance; Magnetic resonance imaging; Medical instruments; Medicine and Health Sciences; Monitoring systems; Novels; Radio frequency; Real time; Research and Analysis Methods; Safety; Safety devices; Scanners; Time; Ventricle; Visualization; Los Angeles California; California; United States > US; Germany
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0229711

Real-time magnetic resonance imaging (MRI) is a promising alternative to X-ray fluoroscopy for guiding cardiovascular catheterization procedures. Major challenges, however, include the lack of guidewires that are compatible with the MRI environment, not susceptible to radiofrequency-induced heating, and reliably visualized. Preclinical evaluation of new guidewire designs has been conducted at 1.5T. Here we further evaluate the safety (device heating), device visualization, and procedural feasibility of 3T MRI-guided cardiovascular catheterization using a novel MRI-visible glass-fiber epoxy-based guidewire in phantoms and porcine models. To evaluate device safety, guidewire tip heating (GTH) was measured in phantom experiments with different combinations of catheters and guidewires. In vivo cardiovascular catheterization procedures were performed in both healthy (N = 5) and infarcted (N = 5) porcine models under real-time 3T MRI guidance using a glass-fiber epoxy-based guidewire. The times for each procedural step were recorded separately. Guidewire visualization was assessed by measuring the dimensions of the guidewire-induced signal void and contrast-to-noise ratio (CNR) between the guidewire tip signal void and the blood signal in real-time gradient-echo MRI (specific absorption rate [SAR] = 0.04 W/kg). In the phantom experiments, GTH did not exceed 0.35°C when using the real-time gradient-echo sequence (SAR = 0.04 W/kg), demonstrating the safety of the glass-fiber epoxy-based guidewire at 3T. The catheter was successfully placed in the left ventricle (LV) under real-time MRI for all five healthy subjects and three out of five infarcted subjects. Signal void dimensions and CNR values showed consistent visualization of the glass-fiber epoxy-based guidewire in real-time MRI. The average time (minutes:seconds) for the catheterization procedure in all subjects was 4:32, although the procedure time varied depending on the subject's specific anatomy (standard deviation = 4:41). Real-time 3T MRI-guided cardiovascular catheterization using a new MRI-visible glass-fiber epoxy-based guidewire is feasible in terms of visualization and guidewire navigation, and safe in terms of radiofrequency-induced guidewire tip heating.