Poststroke depression and risk of recurrent stroke at 1 year in a Chinese cohort study

• Published in: PloS one Vol. 7; no. 10; p. e46906
• Main Authors: Yuan, Huai Wu, Wang, Chun Xue, Zhang, Ning, Bai, Ying, Shi, Yu Zhi, Zhou, Yong, Wang, Yi Long, Zhang, Tong, Zhou, Juan, Yu, Xin, Sun, Xin Yu, Liu, Zhao Rui, Zhao, Xing Quan, Wang, Yong Jun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.10.2012; Public Library of Science (PLoS)
• Subjects: Alcohol use; Antidepressive Agents - therapeutic use; Asian Continental Ancestry Group; Cardiovascular disease; China - epidemiology; Cohort analysis; Cohort Studies; Criteria; Depression (Mood disorder); Depression - etiology; Diabetes; Diagnosis; Diagnostic systems; Drugs; Female; Follow-Up Studies; Health risk assessment; Health risks; Hospitals; Humans; Hypertension; Male; Medicine; Mental depression; Mental disorders; Mental health; Middle Aged; Mortality; Multivariate Analysis; Neurology; Patients; Recurrence; Regression Analysis; Risk; Risk Factors; Statistical analysis; Stroke; Stroke - complications; Stroke - drug therapy; Stroke - epidemiology; Studies; Systematic review; Womens health; China; Beijing China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0046906

Studies show that poststroke depression (PSD) increases mortality risk at 1 year. However, whether PSD increases the risk of recurrent stroke at 1 year remains unclear. This study was to investigate whether PSD at 2 weeks following a stroke could increase risk of recurrent stroke at 1 year. This was a multi-centered prospective cohort study. A total of 2306 patients with acute stroke were enrolled in our study. PSD was diagnosed according to the criteria set by the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV). The outcomes of recurrent stroke were followed up via face-to-face or phone interview. A total of 1713 patients had complete follow-up data, with 481 (28.1%) cases of PSD and 158 (9.2%) cases of cumulative recurrent stroke at 1 year. Multivariate logistic regression analysis showed a 49% increase of OR of recurrent stroke at 1 year in patients with PSD, compared to patients without PSD following a stroke (OR=1.49, 95%CI: 1.03-2.15). There was no significant correlation between anti-depressant drugs and the risk of recurrent stroke at 1 year following a stroke (OR=1.96, 95%: CI 0.95-4.04). Based on the DSM-IV diagnostic criteria, nearly 3 out of 10 hospitalized stroke patients in China were diagnosed with PSD at 2 weeks following a stroke. PSD is associated with a higher risk of recurrent stroke at 1 year. Our study did not find benefit of anti-depressant drugs in reducing such risk.