A retrospective analysis of leucocyte count as a strong predictor of survival for patients with acute paraquat poisoning

The aim of this study is the identification of a reliable predictor of prognosis to optimize the treatment of acute paraquat (PQ) poisoning patients. We performed a retrospective analysis on 96 patients with acute PQ poisoning to evaluate leucocyte count as a predictor of 90-day survival. These pati...

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Bibliographic Details
Published inPloS one Vol. 13; no. 7; p. e0201200
Main Authors Feng, ShunYi, Gao, Jie, Li, Yong
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 25.07.2018
Public Library of Science (PLoS)
Subjects
Analysis
Biology and Life Sciences
Care and treatment
Cell survival
Confidence intervals
Data collection
Emergency medical care
Emergency medical services
Hematology
Herbicides
Hospitals
Leukocytes
Medical prognosis
Medicine and Health Sciences
Mortality
Paraquat
Patients
Poisoning
Prognosis
Statistical models
Survival
White blood cell count
China
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Summary:The aim of this study is the identification of a reliable predictor of prognosis to optimize the treatment of acute paraquat (PQ) poisoning patients. We performed a retrospective analysis on 96 patients with acute PQ poisoning to evaluate leucocyte count as a predictor of 90-day survival. These patients were admitted to the emergency department from May 2012 to February 2017. Kaplan-Meier method was used to compare the 90-day survival. Cox proportional hazard models were utilized to estimate the hazard ratios (HR) and 95% confidence intervals (CI). Receiver operating characteristic (ROC) analysis was conducted to analyze the discriminatory potential of leucocyte with respect to 90-day survival. Result showed that leucocyte was significantly higher among nonsurvivors than that among survivors (p<0.001). Leukocyte was also an independent predictor of survival according to the multivariate Cox analysis (HR 1.103; 95%CI: 1.062-1.146; p<0.001). The area under the curve (AUC) for leucocyte (AUC 0.911; 95%CI: 0.855-0.966; p<0.001) showed a discriminatory potential similar to that of the plasma PQ concentration (AUC 0.961; 95%CI: 0.926-0.997; p<0.001) in predicting 90-day survival. The leucocyte count is a strong predictor of survival in patients with acute PQ poisoning.
Bibliography:Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0201200