Hypertension and risk of psoriasis incidence: An 11-year nationwide population-based cohort study

• Published in: PloS one Vol. 13; no. 8; p. e0202854
• Main Authors: Kim, Ha-Na, Han, Kyungdo, Song, Sang-Wook, Lee, Ji Hyun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 24.08.2018; Public Library of Science (PLoS)
• Subjects: Adult; Adults; Age; Aged; Analysis; Antihypertensives; Biology and Life Sciences; Cohort analysis; Cohort Studies; Confidence intervals; Cytokines; Diabetes; Diabetes mellitus; Dyslipidemia; Family income; Female; Health insurance; Hospitals; Humans; Hypertension; Hypertension - complications; Identity theft; Immune response; Immune system; Incidence; Lymphocytes T; Male; Medical diagnosis; Medicine; Medicine and Health Sciences; Metabolic disorders; Middle Aged; Nonsteroidal anti-inflammatory drugs; Patients; Personal information; Population; Population studies; Population-based studies; Prevalence studies (Epidemiology); Psoriasis; Psoriasis - complications; Psoriasis - epidemiology; Risk; Risk Factors; Skin diseases; Studies; Young Adult; United States > US; South Korea
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0202854

Psoriasis is a chronic inflammatory skin disease that is characterized by T-cell mediated immune response, and has been known to increase the risk of developing hypertension. However, the risk of psoriasis in patients with hypertension is not clear. Therefore, we investigated the risk of psoriasis in patients with hypertension. A total of 256,356 adults (42,726 in the hypertension group and 213,630 in the control group) were followed from 2003 to 2013 in a nationwide population-based cohort study. During the follow-up, 9,254 participants (3.6%) were found to have psoriasis (2,152 [5.0%] in the hypertension group and 7,102 [3.3%] in the control group). The hypertension group had a higher risk of psoriasis incidence (hazard ratio [HR] 1.54, 95% confidence interval [CI] 1.47-1.61, P < 0.001), and the association remained significant after adjusting for comorbidities of diabetes and dyslipidemia, antihypertensive medication and nonsteroidal anti-inflammatory drug use, and sociodemographic factors (HR 1.18, 95% CI 1.08-1.28, P < 0.001). In conclusion, hypertension was significantly associated with an increased risk of psoriasis incidence. Further studies are needed to confirm whether hypertension is associated with the incidence of psoriasis.