Functional gene group analysis indicates no role for heterotrimeric G proteins in cognitive ability

Previous functional gene group analyses implicated common single nucleotide polymorphisms (SNPs) in heterotrimeric G protein coding genes as being associated with differences in human intelligence. Here, we sought to replicate this finding using five independent cohorts of older adults including cur...

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Published inPloS one Vol. 9; no. 3; p. e91690
Main Authors Hill, W David, de Leeuw, Christiaan, Davies, Gail, Liewald, David Cherry McLachlan, Payton, Anthony, Craig, Leone C A, Whalley, Lawrence J, Horan, Mike, Ollier, William, Starr, John M, Pendleton, Neil, Posthuma, Danielle, Bates, Timothy C, Deary, Ian J
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 13.03.2014
Public Library of Science (PLoS)
Subjects
Adults
Aged
Aged, 80 and over
Aging
Analysis
Biology
Child & adolescent psychiatry
Children
Cognition
Cognition & reasoning
Cognitive ability
Epidemiology
Female
G proteins
Genes
Genetic aspects
Genetic Association Studies
Genetic diversity
Genetics
Genomes
Health sciences
Heterotrimeric GTP-Binding Proteins - genetics
Humans
Intelligence
Intelligence - genetics
Intelligence Tests
Male
Mathematics
Medical research
Membrane proteins
Middle Aged
Neurosciences
Older people
Polymorphism, Single Nucleotide
Power
Proteins
Psychology
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Social and Behavioral Sciences
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Summary:Previous functional gene group analyses implicated common single nucleotide polymorphisms (SNPs) in heterotrimeric G protein coding genes as being associated with differences in human intelligence. Here, we sought to replicate this finding using five independent cohorts of older adults including current IQ and childhood IQ, and using both gene- and SNP-based analytic strategies. No significant associations were found between variation in heterotrimeric G protein genes and intelligence in any cohort at either of the two time points. These results indicate that, whereas G protein systems are important in cognition, common genetic variation in these genes is unlikely to be a substantial influence on human intelligence differences.
Bibliography:ObjectType-Article-1
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Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: WDH TCB. Performed the experiments: WDH CdeL. Analyzed the data: WDH CdeL GD. Contributed reagents/materials/analysis tools: DCML LCAC AP MH WO NP DP IJD GD. Wrote the paper: WDH TCB IJD JMS LJW DP.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0091690