EDI OCT evaluation of choroidal thickness in Stargardt disease

• Published in: PloS one Vol. 13; no. 1; p. e0190780
• Main Authors: Sodi, Andrea, Bacherini, Daniela, Lenzetti, Chiara, Caporossi, Orsola, Murro, Vittoria, Mucciolo, Dario Pasquale, Cipollini, Francesca, Passerini, Ilaria, Virgili, Gianni, Rizzo, Stanislao
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.01.2018; Public Library of Science (PLoS)
• Subjects: Acuity; Adult; Age; Age of Onset; Aging - pathology; ATP-Binding Cassette Transporters - genetics; Atrophy; Biology and Life Sciences; Care and treatment; Choroid; Choroid - diagnostic imaging; Diagnosis; Disease; Electroretinograms; Evaluation; Female; Fovea Centralis - diagnostic imaging; Genotype & phenotype; Humans; Macular degeneration; Macular Degeneration - congenital; Macular Degeneration - diagnostic imaging; Macular Degeneration - genetics; Male; Medical examination; Medical imaging; Medicine; Medicine and Health Sciences; Optical tomography; Organ Size; Phenotypes; Physiological aspects; Position measurement; Regression analysis; Research and Analysis Methods; Severity of Illness Index; Social Sciences; Studies; Surgery; Teaching hospitals; Thickness; Tomography, Optical Coherence - methods; Visual Acuity; Visual field; Visual fields; Italy
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0190780

Choroidal thickness (CT) evaluation with EDI-OCT in Stargardt Disease (STGD), considering its possible association with some clinical features of the disease. CT was evaluated in 41 STGD patients and in 70 controls. Measurements were performed in the subfoveal position and at 1000 μm nasally and temporally. CT average values in STGD and in the control group were first compared by means of Student's T test. Then, the possible association between CT and some clinical features was evaluated by means of linear regression analysis. Considered clinical parameters were: age, age on onset, duration of the disease, visual acuity, foveal thickness, Fishman clinical phenotype, visual field loss and ERG response. Average CT was not significantly different between controls and STGD patients. In the STGD group the correlation between CT and age (r = 0.22, p = 0.033) and age of onset (r = 0.05, p = 0.424) was modest, while that of CT with disease duration (r = 0.30, p<0.001) was moderate. CT and foveal thickness were also significantly but modestly correlated (r = 0.15, p = 0.033). In our series average CT is not significantly changed in STGD in comparison with the controls. Nevertheless a choroidal thinning may be identified in the more advanced stages of the disease.