Neural Effects of Auditory Distraction on Visual Attention in Schizophrenia

• Published in: PloS one Vol. 8; no. 4; p. e60606
• Main Authors: Smucny, Jason, Rojas, Donald C., Eichman, Lindsay C., Tregellas, Jason R.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2013; Public Library of Science (PLoS)
• Subjects: Abnormalities; Acoustic Stimulation - psychology; Adult; Analysis; Attention; Attention task; Auditory Perception; Biology; Biomarkers; Brain Mapping; Care and treatment; Case-Control Studies; Cortex (auditory); Cortex (somatosensory); Cross-modal; Diagnosis; Eye movements; Female; Flooding; Functional magnetic resonance imaging; Hippocampus; Hippocampus (Brain); Hippocampus - physiopathology; Humans; Hyperactivity; Listening; Magnetic resonance; Magnetic Resonance Imaging; Male; Medical imaging; Medicine; Memory; Mental disorders; Middle Aged; Neuroimaging; Neuropsychological Tests; Neurosciences; Noise; Noise control; Noise prediction; Parietal Lobe - physiopathology; Patients; Physiological aspects; Prefrontal cortex; Prefrontal Cortex - physiopathology; Psychiatry; Psychotropic drugs; Reaction Time; Reaction time task; Risk factors; Schizophrenia; Schizophrenia - physiopathology; Schizophrenic Psychology; Sensorimotor integration; Sensory integration; Sensory stimulation; Silence; Social and Behavioral Sciences; Somatosensory cortex; Stability; Studies; Task Performance and Analysis; Temporal Lobe - physiopathology; Trends; Visual cortex; Visual Perception; Visual tasks; United States > US; Colorado
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0060606

Sensory flooding, particularly during auditory stimulation, is a common problem for patients with schizophrenia. The functional consequences of this impairment during cross-modal attention tasks, however, are unclear. The purpose of this study was to examine how auditory distraction differentially affects task-associated response during visual attention in patients and healthy controls. To that end, 21 outpatients with schizophrenia and 23 healthy comparison subjects performed a visual attention task in the presence or absence of distracting, environmentally relevant "urban" noise while undergoing functional magnetic resonance imaging at 3T. The task had two conditions (difficult and easy); task-related neural activity was defined as difficult - easy. During task performance, a significant distraction (noise or silence) by group (patient or control) interaction was observed in the left dorsolateral prefrontal cortex, right hippocampus, left temporoparietal junction, and right fusiform gyrus, with patients showing relative hypoactivation during noise compared to controls. In patients, the ability to recruit the dorsolateral prefrontal cortex during the task in noise was negatively correlated with the effect of noise on reaction time. Clinically, the ability to recruit the fusiform gyrus during the task in noise was negatively correlated with SANS affective flattening score, and hippocampal recruitment during the task in noise was positively correlated with global functioning. In conclusion, schizophrenia may be associated with abnormalities in neural response during visual attention tasks in the presence of cross-modal noise distraction. These response differences may predict global functioning in the illness, and may serve as a biomarker for therapeutic development.