Circulating Betatrophin Correlates with Triglycerides and Postprandial Glucose among Different Glucose Tolerance Statuses—A Case-Control Study
Previous researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To further identify the possible impact of betatrophin, we measured the circulating betatrophin levels in newly diagnosed type 2 diabetes (T2DM) patients, and...
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| Published in | PloS one Vol. 10; no. 8; p. e0133640 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
06.08.2015
Public Library of Science (PLoS) |
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| Abstract | Previous researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To further identify the possible impact of betatrophin, we measured the circulating betatrophin levels in newly diagnosed type 2 diabetes (T2DM) patients, and in subjects with both impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) and investigated the relationship between serum betatrophin and other clinical parameters in these patients with different glucose tolerance statuses.
A total of 460 permanent residents of the Fengxian District, aged 40-60 years, were enrolled. Based on the results of a 75 g oral glucose tolerance test, we selected newly diagnosed T2DM (n = 50) patients and subjects with IGT (n = 51) and NGT (n = 50) according to their age, gender and body mass index (18-28 kg/m2). Anthropometric parameters, glycosylated haemoglobin, blood lipids and fasting insulin were measured. Serum betatrophin concentrations were determined via ELISA.
Serum betatrophin levels in T2DM patients were increased significantly compared with IGT and NGT groups, and decreased in subjects with better islet beta cell function. Serum betatrophin was positively correlated with triglyceride, 2-hour postprandial glucose, alanine aminotransferase and aspartate transaminase after adjusting for age, sex and body mass index in all subjects. Multiple regression analysis showed that 2-hour postprandial glucose was independently associated with serum betatrophin significantly.
Circulating betatrophin is increased in newly-diagnosed T2DM patients and positively correlated with the triglycerides and postprandial glucose levels. The results suggest that betatrophin may participate in glucose and triglycerides metabolism. |
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| AbstractList | PurposePrevious researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To further identify the possible impact of betatrophin, we measured the circulating betatrophin levels in newly diagnosed type 2 diabetes (T2DM) patients, and in subjects with both impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) and investigated the relationship between serum betatrophin and other clinical parameters in these patients with different glucose tolerance statuses.MethodsA total of 460 permanent residents of the Fengxian District, aged 40-60 years, were enrolled. Based on the results of a 75 g oral glucose tolerance test, we selected newly diagnosed T2DM (n = 50) patients and subjects with IGT (n = 51) and NGT (n = 50) according to their age, gender and body mass index (18-28 kg/m2). Anthropometric parameters, glycosylated haemoglobin, blood lipids and fasting insulin were measured. Serum betatrophin concentrations were determined via ELISA.ResultsSerum betatrophin levels in T2DM patients were increased significantly compared with IGT and NGT groups, and decreased in subjects with better islet beta cell function. Serum betatrophin was positively correlated with triglyceride, 2-hour postprandial glucose, alanine aminotransferase and aspartate transaminase after adjusting for age, sex and body mass index in all subjects. Multiple regression analysis showed that 2-hour postprandial glucose was independently associated with serum betatrophin significantly.ConclusionsCirculating betatrophin is increased in newly-diagnosed T2DM patients and positively correlated with the triglycerides and postprandial glucose levels. The results suggest that betatrophin may participate in glucose and triglycerides metabolism. Previous researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To further identify the possible impact of betatrophin, we measured the circulating betatrophin levels in newly diagnosed type 2 diabetes (T2DM) patients, and in subjects with both impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) and investigated the relationship between serum betatrophin and other clinical parameters in these patients with different glucose tolerance statuses. A total of 460 permanent residents of the Fengxian District, aged 40-60 years, were enrolled. Based on the results of a 75 g oral glucose tolerance test, we selected newly diagnosed T2DM (n = 50) patients and subjects with IGT (n = 51) and NGT (n = 50) according to their age, gender and body mass index (18-28 kg/m.sup.2). Anthropometric parameters, glycosylated haemoglobin, blood lipids and fasting insulin were measured. Serum betatrophin concentrations were determined via ELISA. Serum betatrophin levels in T2DM patients were increased significantly compared with IGT and NGT groups, and decreased in subjects with better islet beta cell function. Serum betatrophin was positively correlated with triglyceride, 2-hour postprandial glucose, alanine aminotransferase and aspartate transaminase after adjusting for age, sex and body mass index in all subjects. Multiple regression analysis showed that 2-hour postprandial glucose was independently associated with serum betatrophin significantly. Circulating betatrophin is increased in newly-diagnosed T2DM patients and positively correlated with the triglycerides and postprandial glucose levels. The results suggest that betatrophin may participate in glucose and triglycerides metabolism. Previous researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To further identify the possible impact of betatrophin, we measured the circulating betatrophin levels in newly diagnosed type 2 diabetes (T2DM) patients, and in subjects with both impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) and investigated the relationship between serum betatrophin and other clinical parameters in these patients with different glucose tolerance statuses. A total of 460 permanent residents of the Fengxian District, aged 40-60 years, were enrolled. Based on the results of a 75 g oral glucose tolerance test, we selected newly diagnosed T2DM (n = 50) patients and subjects with IGT (n = 51) and NGT (n = 50) according to their age, gender and body mass index (18-28 kg/m2). Anthropometric parameters, glycosylated haemoglobin, blood lipids and fasting insulin were measured. Serum betatrophin concentrations were determined via ELISA. Serum betatrophin levels in T2DM patients were increased significantly compared with IGT and NGT groups, and decreased in subjects with better islet beta cell function. Serum betatrophin was positively correlated with triglyceride, 2-hour postprandial glucose, alanine aminotransferase and aspartate transaminase after adjusting for age, sex and body mass index in all subjects. Multiple regression analysis showed that 2-hour postprandial glucose was independently associated with serum betatrophin significantly. Circulating betatrophin is increased in newly-diagnosed T2DM patients and positively correlated with the triglycerides and postprandial glucose levels. The results suggest that betatrophin may participate in glucose and triglycerides metabolism. Purpose Previous researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To further identify the possible impact of betatrophin, we measured the circulating betatrophin levels in newly diagnosed type 2 diabetes (T2DM) patients, and in subjects with both impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) and investigated the relationship between serum betatrophin and other clinical parameters in these patients with different glucose tolerance statuses. Methods A total of 460 permanent residents of the Fengxian District, aged 40–60 years, were enrolled. Based on the results of a 75 g oral glucose tolerance test, we selected newly diagnosed T2DM (n = 50) patients and subjects with IGT (n = 51) and NGT (n = 50) according to their age, gender and body mass index (18–28 kg/m2). Anthropometric parameters, glycosylated haemoglobin, blood lipids and fasting insulin were measured. Serum betatrophin concentrations were determined via ELISA. Results Serum betatrophin levels in T2DM patients were increased significantly compared with IGT and NGT groups, and decreased in subjects with better islet beta cell function. Serum betatrophin was positively correlated with triglyceride, 2-hour postprandial glucose, alanine aminotransferase and aspartate transaminase after adjusting for age, sex and body mass index in all subjects. Multiple regression analysis showed that 2-hour postprandial glucose was independently associated with serum betatrophin significantly. Conclusions Circulating betatrophin is increased in newly-diagnosed T2DM patients and positively correlated with the triglycerides and postprandial glucose levels. The results suggest that betatrophin may participate in glucose and triglycerides metabolism. Purpose Previous researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To further identify the possible impact of betatrophin, we measured the circulating betatrophin levels in newly diagnosed type 2 diabetes (T2DM) patients, and in subjects with both impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) and investigated the relationship between serum betatrophin and other clinical parameters in these patients with different glucose tolerance statuses. Methods A total of 460 permanent residents of the Fengxian District, aged 40-60 years, were enrolled. Based on the results of a 75 g oral glucose tolerance test, we selected newly diagnosed T2DM (n = 50) patients and subjects with IGT (n = 51) and NGT (n = 50) according to their age, gender and body mass index (18-28 kg/m.sup.2). Anthropometric parameters, glycosylated haemoglobin, blood lipids and fasting insulin were measured. Serum betatrophin concentrations were determined via ELISA. Results Serum betatrophin levels in T2DM patients were increased significantly compared with IGT and NGT groups, and decreased in subjects with better islet beta cell function. Serum betatrophin was positively correlated with triglyceride, 2-hour postprandial glucose, alanine aminotransferase and aspartate transaminase after adjusting for age, sex and body mass index in all subjects. Multiple regression analysis showed that 2-hour postprandial glucose was independently associated with serum betatrophin significantly. Conclusions Circulating betatrophin is increased in newly-diagnosed T2DM patients and positively correlated with the triglycerides and postprandial glucose levels. The results suggest that betatrophin may participate in glucose and triglycerides metabolism. Purpose Previous researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To further identify the possible impact of betatrophin, we measured the circulating betatrophin levels in newly diagnosed type 2 diabetes (T2DM) patients, and in subjects with both impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) and investigated the relationship between serum betatrophin and other clinical parameters in these patients with different glucose tolerance statuses. Methods A total of 460 permanent residents of the Fengxian District, aged 40–60 years, were enrolled. Based on the results of a 75 g oral glucose tolerance test, we selected newly diagnosed T2DM (n = 50) patients and subjects with IGT (n = 51) and NGT (n = 50) according to their age, gender and body mass index (18–28 kg/m2). Anthropometric parameters, glycosylated haemoglobin, blood lipids and fasting insulin were measured. Serum betatrophin concentrations were determined via ELISA. Results Serum betatrophin levels in T2DM patients were increased significantly compared with IGT and NGT groups, and decreased in subjects with better islet beta cell function. Serum betatrophin was positively correlated with triglyceride, 2-hour postprandial glucose, alanine aminotransferase and aspartate transaminase after adjusting for age, sex and body mass index in all subjects. Multiple regression analysis showed that 2-hour postprandial glucose was independently associated with serum betatrophin significantly. Conclusions Circulating betatrophin is increased in newly-diagnosed T2DM patients and positively correlated with the triglycerides and postprandial glucose levels. The results suggest that betatrophin may participate in glucose and triglycerides metabolism. Previous researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To further identify the possible impact of betatrophin, we measured the circulating betatrophin levels in newly diagnosed type 2 diabetes (T2DM) patients, and in subjects with both impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) and investigated the relationship between serum betatrophin and other clinical parameters in these patients with different glucose tolerance statuses.PURPOSEPrevious researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To further identify the possible impact of betatrophin, we measured the circulating betatrophin levels in newly diagnosed type 2 diabetes (T2DM) patients, and in subjects with both impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) and investigated the relationship between serum betatrophin and other clinical parameters in these patients with different glucose tolerance statuses.A total of 460 permanent residents of the Fengxian District, aged 40-60 years, were enrolled. Based on the results of a 75 g oral glucose tolerance test, we selected newly diagnosed T2DM (n = 50) patients and subjects with IGT (n = 51) and NGT (n = 50) according to their age, gender and body mass index (18-28 kg/m2). Anthropometric parameters, glycosylated haemoglobin, blood lipids and fasting insulin were measured. Serum betatrophin concentrations were determined via ELISA.METHODSA total of 460 permanent residents of the Fengxian District, aged 40-60 years, were enrolled. Based on the results of a 75 g oral glucose tolerance test, we selected newly diagnosed T2DM (n = 50) patients and subjects with IGT (n = 51) and NGT (n = 50) according to their age, gender and body mass index (18-28 kg/m2). Anthropometric parameters, glycosylated haemoglobin, blood lipids and fasting insulin were measured. Serum betatrophin concentrations were determined via ELISA.Serum betatrophin levels in T2DM patients were increased significantly compared with IGT and NGT groups, and decreased in subjects with better islet beta cell function. Serum betatrophin was positively correlated with triglyceride, 2-hour postprandial glucose, alanine aminotransferase and aspartate transaminase after adjusting for age, sex and body mass index in all subjects. Multiple regression analysis showed that 2-hour postprandial glucose was independently associated with serum betatrophin significantly.RESULTSSerum betatrophin levels in T2DM patients were increased significantly compared with IGT and NGT groups, and decreased in subjects with better islet beta cell function. Serum betatrophin was positively correlated with triglyceride, 2-hour postprandial glucose, alanine aminotransferase and aspartate transaminase after adjusting for age, sex and body mass index in all subjects. Multiple regression analysis showed that 2-hour postprandial glucose was independently associated with serum betatrophin significantly.Circulating betatrophin is increased in newly-diagnosed T2DM patients and positively correlated with the triglycerides and postprandial glucose levels. The results suggest that betatrophin may participate in glucose and triglycerides metabolism.CONCLUSIONSCirculating betatrophin is increased in newly-diagnosed T2DM patients and positively correlated with the triglycerides and postprandial glucose levels. The results suggest that betatrophin may participate in glucose and triglycerides metabolism. |
| Audience | Academic |
| Author | Gao, Ting Jin, Kairui Jin, Hua Yang, Meili Yang, Lili Xie, Xinmiao Yu, Xuemei Chen, Peihong Hu, Cheng |
| AuthorAffiliation | University of Catanzaro Magna Graecia, ITALY 3 Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China 2 Department of Clinical Medicine, Fudan University Shanghai Medical College, Shanghai, China 1 Department of Endocrinology and Metabolism, Fengxian Central Hospital, South District of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China |
| AuthorAffiliation_xml | – name: 3 Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China – name: 1 Department of Endocrinology and Metabolism, Fengxian Central Hospital, South District of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China – name: University of Catanzaro Magna Graecia, ITALY – name: 2 Department of Clinical Medicine, Fudan University Shanghai Medical College, Shanghai, China |
| Author_xml | – sequence: 1 givenname: Ting surname: Gao fullname: Gao, Ting – sequence: 2 givenname: Kairui surname: Jin fullname: Jin, Kairui – sequence: 3 givenname: Peihong surname: Chen fullname: Chen, Peihong – sequence: 4 givenname: Hua surname: Jin fullname: Jin, Hua – sequence: 5 givenname: Lili surname: Yang fullname: Yang, Lili – sequence: 6 givenname: Xinmiao surname: Xie fullname: Xie, Xinmiao – sequence: 7 givenname: Meili surname: Yang fullname: Yang, Meili – sequence: 8 givenname: Cheng surname: Hu fullname: Hu, Cheng – sequence: 9 givenname: Xuemei surname: Yu fullname: Yu, Xuemei |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26247824$$D View this record in MEDLINE/PubMed |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: XY. Performed the experiments: TG PC HJ LY XX MY. Analyzed the data: XY KJ CH. Contributed reagents/materials/analysis tools: TG PC HJ LY XX MY CH XY. Wrote the paper: KJ CH XY. Read and approved the final manuscript: TG KJ PC HJ LY XX MY CH XY. Competing Interests: The authors have declared that no competing interests exist. |
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| References | P Yi (ref4) 2013; 153 R Zhang (ref21) 2013; 432 Z Fu (ref7) 2014; 4 D Espes (ref8) 2014 K Guo 1 (ref12) 2015; 23 A Fenzl (ref10) 2014; 57 P Yi (ref14) 2014; 159 Xinmiao Xie (ref15) 2015; 7 MW Stolar (ref2) 2008; 14 A Bagust (ref3) 2003; 96 J Gómez-Ambrosi (ref9) 2014; 99 G Ren 1 (ref17) 2012; 303 R Zhang (ref20) 2012; 424 F Quagliarini (ref18) 2012; 109 Y Jiao (ref13) 2014; 63 D Espes (ref6) 2014; 57 F Sanchis-Gomar (ref16) 2014; 3 H Hu (ref11) 2014; 37 Y Wang (ref19) 2013; 110 W Yang (ref1) 2010; 362 Viktoria Gusarova (ref5) 2014; 159 |
| References_xml | – volume: 424 start-page: 786 year: 2012 ident: ref20 article-title: Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2012.07.038 – volume: 153 start-page: 747 year: 2013 ident: ref4 article-title: Betatrophin: a hormone that controls pancreatic β cell proliferation publication-title: Cell doi: 10.1016/j.cell.2013.04.008 – volume: 109 start-page: 19751 year: 2012 ident: ref18 article-title: Atypical angiopoietin-likeprotein that regulates ANGPTL3 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1217552109 – volume: 57 start-page: 50 year: 2014 ident: ref6 article-title: Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes publication-title: Diabetologia doi: 10.1007/s00125-013-3071-1 – volume: 4 start-page: 5013 year: 2014 ident: ref7 article-title: Elevated circulating lipasin/ betatrophin in human type 2 diabetes and obesity publication-title: Sci Rep doi: 10.1038/srep05013 – volume: 3 start-page: 67 year: 2014 ident: ref16 article-title: The p38-PGC-1alpha-irisin-betatrophin axis: exploring new pathways in insulin resistance publication-title: Adipocytes doi: 10.4161/adip.27370 – volume: 57 start-page: 1204 year: 2014 ident: ref10 article-title: Circulating betatrophin correlates with atherogenic lipid profiles but not with glucose and insulin levels in insulin-resistant individuals publication-title: Diabetologia doi: 10.1007/s00125-014-3208-x – volume: 63 start-page: 1283 year: 2014 ident: ref13 article-title: Elevated mouse hepatic betatrophin expression does not increase human beta-cell replication in the transplant setting publication-title: Diabetes doi: 10.2337/db13-1435 – volume: 110 start-page: 16109 year: 2013 ident: ref19 article-title: Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1315292110 – volume: 96 start-page: 281 year: 2003 ident: ref3 article-title: Deteriorating beta-cell function in type 2 diabetes: a long-term model publication-title: QJM doi: 10.1093/qjmed/hcg040 – volume: 14 start-page: 2 year: 2008 ident: ref2 article-title: Managing type 2 diabetes: going beyond glycemic control publication-title: J Manag Care Pharm – volume: 159 start-page: 691 year: 2014 ident: ref5 article-title: ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion publication-title: Cell doi: 10.1016/j.cell.2014.09.027 – volume: 7 start-page: 26 year: 2015 ident: ref15 article-title: Associations of betatrophin levels with irisin in Chinese women with normal glucose tolerance publication-title: Diabetology & Metabolic Syndrome doi: 10.1186/s13098-015-0019-2 – volume: 362 start-page: 1090 year: 2010 ident: ref1 article-title: Prevalence of diabetes among men and women in China publication-title: N Engl J Med doi: 10.1056/NEJMoa0908292 – volume: 37 start-page: 2718 year: 2014 ident: ref11 article-title: Increased circulating levels of betatrophin in newly diagnosed type 2 diabetic patients publication-title: Diabetes Care doi: 10.2337/dc14-0602 – volume: 23 start-page: 793 year: 2015 ident: ref12 article-title: Serum betatrophin concentrations are significantly increased in overweight but not in obese or type 2 diabetic individuals publication-title: Obesity doi: 10.1002/oby.21038 – volume: 432 start-page: 401 year: 2013 ident: ref21 article-title: Emerging roles of Lipasin as a critical lipid regulator publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2013.01.129 – volume: 99 start-page: E2004 year: 2014 ident: ref9 article-title: Circulating betatrophin concentrations are decreased in human obesity and type 2 diabetes publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2014-1568 – volume: 303 start-page: E334 year: 2012 ident: ref17 article-title: Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00084.2012 – year: 2014 ident: ref8 article-title: Increased circulating betatrophin concentrations in patients with type 2 diabetes publication-title: Int J Endocrinol – volume: 159 start-page: 467 year: 2014 ident: ref14 article-title: Perspectives on the activities ofANGPTL8/betatrophin publication-title: Cell doi: 10.1016/j.cell.2014.09.028 |
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| Snippet | Previous researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To further... Purpose Previous researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To... PurposePrevious researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To further... Purpose Previous researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To... |
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| SubjectTerms | Adult Alanine Alanine transaminase Alanine Transaminase - blood Angiopoietin-like Proteins Anthropometry Aspartate Aminotransferases - blood Aspartate transaminase Beta cells Blood Glucose - analysis Body mass Body mass index Body size Care and treatment Case-Control Studies Cell growth Correlation Development and progression Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - diagnosis Diabetic retinopathy Diagnosis Endocrinology Enzyme-Linked Immunosorbent Assay Female Gender Glucose Glucose Intolerance - pathology Glucose metabolism Glucose tolerance Glucose Tolerance Test Hemoglobin Homeostasis Hospitals Humans Indexing Insulin Insulin resistance Islets of Langerhans Lipid metabolism Lipids Male Metabolism Middle Aged Multiple regression analysis Obesity Pancreatic beta cells Parameters Patients Peptide Hormones - blood Physiological aspects Postprandial Period Regression Analysis Risk factors Transaminase Triglycerides Triglycerides - blood Type 2 diabetes |
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| Title | Circulating Betatrophin Correlates with Triglycerides and Postprandial Glucose among Different Glucose Tolerance Statuses—A Case-Control Study |
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