Circulating Betatrophin Correlates with Triglycerides and Postprandial Glucose among Different Glucose Tolerance Statuses—A Case-Control Study

• Published in: PloS one Vol. 10; no. 8; p. e0133640
• Main Authors: Gao, Ting, Jin, Kairui, Chen, Peihong, Jin, Hua, Yang, Lili, Xie, Xinmiao, Yang, Meili, Hu, Cheng, Yu, Xuemei
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.08.2015; Public Library of Science (PLoS)
• Subjects: Adult; Alanine; Alanine transaminase; Alanine Transaminase - blood; Angiopoietin-like Proteins; Anthropometry; Aspartate Aminotransferases - blood; Aspartate transaminase; Beta cells; Blood Glucose - analysis; Body mass; Body mass index; Body size; Care and treatment; Case-Control Studies; Cell growth; Correlation; Development and progression; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - diagnosis; Diabetic retinopathy; Diagnosis; Endocrinology; Enzyme-Linked Immunosorbent Assay; Female; Gender; Glucose; Glucose Intolerance - pathology; Glucose metabolism; Glucose tolerance; Glucose Tolerance Test; Hemoglobin; Homeostasis; Hospitals; Humans; Indexing; Insulin; Insulin resistance; Islets of Langerhans; Lipid metabolism; Lipids; Male; Metabolism; Middle Aged; Multiple regression analysis; Obesity; Pancreatic beta cells; Parameters; Patients; Peptide Hormones - blood; Physiological aspects; Postprandial Period; Regression Analysis; Risk factors; Transaminase; Triglycerides; Triglycerides - blood; Type 2 diabetes; United States; United States > US; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0133640

Previous researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To further identify the possible impact of betatrophin, we measured the circulating betatrophin levels in newly diagnosed type 2 diabetes (T2DM) patients, and in subjects with both impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) and investigated the relationship between serum betatrophin and other clinical parameters in these patients with different glucose tolerance statuses. A total of 460 permanent residents of the Fengxian District, aged 40-60 years, were enrolled. Based on the results of a 75 g oral glucose tolerance test, we selected newly diagnosed T2DM (n = 50) patients and subjects with IGT (n = 51) and NGT (n = 50) according to their age, gender and body mass index (18-28 kg/m2). Anthropometric parameters, glycosylated haemoglobin, blood lipids and fasting insulin were measured. Serum betatrophin concentrations were determined via ELISA. Serum betatrophin levels in T2DM patients were increased significantly compared with IGT and NGT groups, and decreased in subjects with better islet beta cell function. Serum betatrophin was positively correlated with triglyceride, 2-hour postprandial glucose, alanine aminotransferase and aspartate transaminase after adjusting for age, sex and body mass index in all subjects. Multiple regression analysis showed that 2-hour postprandial glucose was independently associated with serum betatrophin significantly. Circulating betatrophin is increased in newly-diagnosed T2DM patients and positively correlated with the triglycerides and postprandial glucose levels. The results suggest that betatrophin may participate in glucose and triglycerides metabolism.