Effects of selenium supplementation on glycemic control markers in healthy rodents: A systematic review protocol

• Published in: PloS one Vol. 17; no. 4; p. e0261985
• Main Authors: Ferreira, Rannapaula Lawrynhuk Urbano, de Sousa, Ângela Waleska Freire, Oliveira, Antonio Gouveia, de Rezende, Adriana Augusto, Cobucci, Ricardo Ney, Pedrosa, Lucia Fatima Campos
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.04.2022; Public Library of Science (PLoS)
• Subjects: Analysis; Animal experimentation; Animal models; Animals; Antioxidants; Bias; Biology and Life Sciences; Biomarkers; Blood glucose; Blood sugar; Clinical trials; Diabetes; Dietary Supplements; Erythrocytes; Evaluation; Experimentation; Gene expression; Glucose; Glycemic Control; Glycemic index; In vivo methods and tests; Insulin; Insulin resistance; Laboratory animals; Literature reviews; Medicine and Health Sciences; Meta-analysis; Meta-Analysis as Topic; Metabolism; Modelling; Nanoparticles; Nutrition research; Physical Sciences; Polysaccharides; Research and Analysis Methods; Reviews; Risk analysis; Rodentia; Rodents; Saccharides; Selenium; Study Protocol; Supplements; Synthesis; Systematic review; Systematic Reviews as Topic; Yeasts; Brazil
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0261985

In vivo and in vitro studies have shown that Se has an insulin-mimetic action associated with its antioxidant activity. Other studies, in turn, suggest that high Se doses and high selenoprotein expression interfere with insulin signaling. This study aims to evaluate the effects of Se supplementation on glycemic control markers in healthy rodents. The protocol was developed according to the Preferred Reporting Items for Systematic Review and Metaanalysis Protocol (PRISMA-P) and was published in the International Prospective Register of Systematic Reviews database (PROSPERO; CRD4202121201142019119181). Experimental, randomized, or non-randomized studies of healthy rodents models will be included. All forms of supplemented Se will be considered, including organic, inorganic, and synthetic compounds, selenium-enriched yeasts, zerovalent Se nanoparticles, and selenized polysaccharides. Fasting blood glucose will be considered the primary outcome. Homeostatic model assessment, plasma and erythrocyte Se concentration, GPX activity, SELENOP concentration, and other Se biomarkers will be considered secondary outcomes. EMBASE, Scopus, Pubmed/Medline, Web of Science, and CINAHL will be searched for articles published with no language restrictions. Two reviewers will independently conduct the search and selection of articles, data extraction, and quality analysis. The risk of bias and methodological quality analyses of the included studies will be performed using the Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) and Collaborative Approach to Meta-Analysis and Review (CAMARADES) tools, respectively. The results will be presented as a narrative synthesis according to the Synthesis Without Meta-analysis (SWiM) Reporting Guideline. Meta-analyses will be conducted where appropriate using random-effects models. The review may clarify the interaction between different forms of supplemented Se and glycemic control in rodents models. The results will provide evidence that will help select doses and forms of Se to administer in clinical trials while according to impact on the glycemic control while elucidating mechanisms of Se metabolism.