Outcomes of Surgical Repair for Persistent Truncus Arteriosus from Neonates to Adults: A Single Center's Experience

This study aimed to report our experiences with surgical repair in patients of all ages with persistent truncus arteriosus. From July 2004 to July 2014, 50 consecutive patients with persistent truncus arteriosus who underwent anatomical repair were included in the retrospective review. Median follow...

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Published inPloS one Vol. 11; no. 1; p. e0146800
Main Authors Chen, Qiuming, Gao, Huawei, Hua, Zhongdong, Yang, Keming, Yan, Jun, Zhang, Hao, Ma, Kai, Zhang, Sen, Qi, Lei, Li, Shoujun
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 11.01.2016
Public Library of Science (PLoS)
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Summary:This study aimed to report our experiences with surgical repair in patients of all ages with persistent truncus arteriosus. From July 2004 to July 2014, 50 consecutive patients with persistent truncus arteriosus who underwent anatomical repair were included in the retrospective review. Median follow-up time was 3.4 years (range, 3 months to 10 years). Fifty patients underwent anatomical repair at a median age of 19.6 months (range, 20 days to 19.1 years). Thirty patients (60%) were older than one year. The preoperative pulmonary vascular resistance and mean pulmonary artery pressure were 4.1±2.1 (range, 0.1 to 8.9) units.m2 and 64.3±17.9 (range, 38 to 101) mmHg, respectively. Significant truncal valve regurgitation was presented in 14 (28%) patients. Hospital death occurred in 3 patients, two due to pulmonary hypertensive crisis and the other due to pneumonia. Three late deaths occurred at 3, 4 and 11 months after surgery. The actuarial survival rates were 87.7% and 87.7% at 1 year and 5 years, respectively. Multivariate analysis identified significant preoperative truncal valve regurgitation was a risk factor for overall mortality (odds ratio, 7.584; 95%CI: 1.335-43.092; p = 0.022). Two patients required reoperation of truncal valve replacement. One patient underwent reintervention for conduit replacement. Freedom from reoperation at 5 years was 92.9%. At latest examination, there was one patient with moderate-to-severe truncal valve regurgitation and four with moderate. Three patients had residual pulmonary artery hypertension. All survivors were in New York Heart Association class I-II. Complete repair of persistent truncus arteriosus can be achieved with a relatively low mortality and acceptable early- and mid-term results, even in cases with late presentation. Significant preoperative truncal valve regurgitation remains a risk factor for overall mortality. The long-term outcomes warrant further follow-up.
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Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: QC SL. Performed the experiments: QC SL HG ZH KY JY HZ KM SZ LQ. Analyzed the data: QC SL HG KM. Contributed reagents/materials/analysis tools: QC SL KM. Wrote the paper: QC SL HG KM SZ LQ.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0146800