MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug

• Published in: PloS one Vol. 14; no. 8; p. e0214900
• Main Authors: Alfaro, Aline, León, Andrea, Guajardo-Correa, Emanuel, Reúquen, Patricia, Torres, Francisco, Mery, Mario, Segura, Rodrigo, Zapata, Paula A, Orihuela, Pedro A
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 15.08.2019; Public Library of Science (PLoS)
• Subjects: 2-Methoxyestradiol - chemistry; 2-Methoxyestradiol - pharmacology; Absorption, Physicochemical; Antineoplastic agents; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biology and Life Sciences; Cancer therapies; Cell Line, Tumor; Cell Survival - drug effects; Chemical properties; Dosage and administration; Drug Carriers - chemistry; Drug Carriers - toxicity; Drug delivery; Drug delivery systems; Drug Liberation; Drug therapy; Engineering and Technology; Fourier transforms; Glycols (Class of compounds); Humans; Infrared spectroscopy; Kinetics; Magnesium; Magnesium compounds; Magnesium oxide; Magnesium Oxide - chemistry; Magnesium Oxide - toxicity; Materials; Medicine and Health Sciences; Models, Molecular; Molecular Conformation; Nanocomposites; Nanoparticles; Nanoparticles - chemistry; Novels; Physical Sciences; Polyethylene glycol; Polyethylene Glycols - chemistry; Polymer industry; Polymers; Polyols; Product development; Prostate cancer; Research and Analysis Methods; Spectroscopy; Superconductors (materials); Surfactants; Viability; Vibration; Vibration mode; Chile; United States > US
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0214900

Novel Magnesium Oxide (MgO) nanoparticles (NPs) modified with the polymer polyethylene glycol (PEG) were synthesized as carrier for the anticancer drug 2-Methoxyestradiol (2ME) to improve its clinical application. The functionalized NPs were characterized by Infrared spectroscopy with Fourier transform to elucidate the vibration modes of this conjugate, indicating the formation of the MgO-PEG-2ME nanocomposite. The studies of absorption and liberation determined that MgO-PEG-2ME NPs incorporated 98.51 % of 2ME while liberation of 2ME was constant during 7 days at pH 2, 5 and 7.35. Finally, the MgO-PEG-2ME NPs decreased the viability of the prostate cancer cell line LNCap suggesting that this nanocomposite is suitable as a drug delivery system for anticancer prostate therapy.