Differential Involvement of the Dentate Gyrus in Adaptive Forgetting in the Rat

• Published in: PloS one Vol. 10; no. 11; p. e0142065
• Main Authors: Joseph, Mickaël Antoine, Fraize, Nicolas, Ansoud-Lerouge, Jennifer, Sapin, Emilie, Peyron, Christelle, Arthaud, Sébastien, Libourel, Paul-Antoine, Parmentier, Régis, Salin, Paul Antoine, Malleret, Gaël
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.11.2015; Public Library of Science (PLoS)
• Subjects: Adaptation, Psychological - physiology; Adaptive structures; Analysis; Animal memory; Animals; Biological markers; Brain; Brain research; c-Fos protein; Dentate gyrus; Dentate Gyrus - physiology; Early Growth Response Protein 1 - biosynthesis; EGR-1 protein; Fos protein; Gene expression; Gene Expression Regulation - physiology; Genetic aspects; Interference; Kinases; Locomotion; Long term care; Memory, Short-Term - physiology; Motivation; Neurogenesis; Neuronal Plasticity - physiology; Neurons - metabolism; Neurosciences; Proactive interference; Proto-Oncogene Proteins c-fos - biosynthesis; Rats; Rodents; Short term memory; Storage; Studies; Synaptic plasticity; Trends; United States
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0142065

How does the brain discriminate essential information aimed to be stored permanently from information required only temporarily, and that needs to be cleared away for not saturating our precious memory space? Reference Memory (RM) refers to the long-term storage of invariable information whereas Working Memory (WM) depends on the short-term storage of trial-unique information. Previous work has revealed that WM tasks are very sensitive to proactive interference. In order to prevent such interference, irrelevant old memories must be forgotten to give new ones the opportunity to be stabilized. However, unlike memory, physiological processes underlying this adaptive form of forgetting are still poorly understood. Here, we precisely ask what specific brain structure(s) could be responsible for such process to occur. To answer this question, we trained rats in a radial maze using three paradigms, a RM task and two WM tasks involving or not the processing of interference but strictly identical in terms of locomotion or motivation. We showed that an inhibition of the expression of Zif268 and c-Fos, two indirect markers of neuronal activity and synaptic plasticity, was observed in the dentate gyrus of the dorsal hippocampus when processing such interfering previously stored information. Conversely, we showed that inactivating the dentate gyrus impairs both RM and WM, but improves the processing of interference. Altogether, these results strongly suggest for the first time that the dentate gyrus could be a key structure involved in adaptive forgetting.