Exposure to Hyperbaric Oxygen Intensified Vancomycin-Induced Nephrotoxicity in Rats

• Published in: PloS one Vol. 11; no. 4; p. e0152554
• Main Authors: Sabler, Itay M., Berkovitch, Matitiahu, Sandbank, Judith, Kozer, Eran, Dagan, Zahi, Goldman, Michael, Bahat, Hilla, Stav, Kobi, Zisman, Amnon, Klin, Baruch, Abu-Kishk, Ibrahim
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.04.2016; Public Library of Science (PLoS)
• Subjects: Anesthesia; Animal models; Animals; Antibiotics; Biology and Life Sciences; Blood; Blood levels; Blood Urea Nitrogen; Carbon dioxide; Care and treatment; Creatinine; Creatinine - blood; Disease Models, Animal; Dosage and administration; Drug dosages; Enzymes; Experiments; Exposure; Gene expression; Hyperbaric oxygen therapy; Hyperbaric oxygenation; Hyperbaric Oxygenation - adverse effects; Hyperbaric Oxygenation - methods; Hypoxia; Kidney - drug effects; Kidney diseases; Kidney Diseases - blood; Kidney Diseases - chemically induced; Kidney Function Tests - methods; Kidneys; Magnesium; Magnesium - blood; Male; Medicine; Medicine and Health Sciences; Methods; Nephrology; Oxidative stress; Oxidative Stress - drug effects; Oxygen; Oxygen - adverse effects; Oxygen therapy; Pediatrics; Pharmacology; Physical Sciences; Rats; Rats, Sprague-Dawley; Rodents; Studies; Therapy; Toxicity; Tuberculosis; Urea; Urology; Vancomycin; Vancomycin - adverse effects
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0152554

It has been suggested that oxidative stress is a potential mechanism for vancomycin-induced nephrotoxicity and hyperbaric oxygen therapy (HBO) has been shown to be effective in treating renal toxicity that has been pharmacologically induced in animal models. The aim of this study was to investigate...