Pancreatic cancer patient survival correlates with DNA methylation of pancreas development genes

DNA methylation is an epigenetic mark associated with regulation of transcription and genome structure. These markers have been investigated in a variety of cancer settings for their utility in differentiating normal tissue from tumor tissue. Here, we examine the direct correlation between DNA methy...

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Bibliographic Details
Published inPloS one Vol. 10; no. 6; p. e0128814
Main Authors Thompson, Michael J, Rubbi, Liudmilla, Dawson, David W, Donahue, Timothy R, Pellegrini, Matteo
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 03.06.2015
Public Library of Science (PLoS)
Subjects
Aged
Aged, 80 and over
Biomarkers
Cancer
Cancer therapies
Care and treatment
Chromosomes
CpG Islands
Deoxyribonucleic acid
Development and progression
Developmental biology
Disease Progression
DNA
DNA Methylation
Epigenesis, Genetic
Female
Gene expression
Gene Expression Profiling
Gene regulation
Genes
Genetic aspects
Genomes
Genomics
High-Throughput Nucleotide Sequencing
Humans
Lymphatic Metastasis
Male
Medical prognosis
Medical research
Metastasis
Methylation
Middle Aged
Molecular Sequence Annotation
Mutation
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Neoplasm Staging
Pancreas
Pancreas - metabolism
Pancreas - pathology
Pancreatic cancer
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - genetics
Pancreatic Neoplasms - mortality
Pancreatic Neoplasms - pathology
Pancreatitis
Pancreatitis - diagnosis
Pancreatitis - genetics
Pancreatitis - pathology
Patient outcomes
Patients
Pediatrics
Physiological aspects
Principal Component Analysis
Principal components analysis
Survival
Survival Analysis
Technology application
Transcription
Tumor Burden
United States
Los Angeles California
United States > US
California
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Summary:DNA methylation is an epigenetic mark associated with regulation of transcription and genome structure. These markers have been investigated in a variety of cancer settings for their utility in differentiating normal tissue from tumor tissue. Here, we examine the direct correlation between DNA methylation and patient survival. We find that changes in the DNA methylation of key pancreatic developmental genes are strongly associated with patient survival.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Competing Interests: The authors have declared no competing interests exist.
Conceived and designed the experiments: MT MP. Performed the experiments: LR. Analyzed the data: MT. Contributed reagents/materials/analysis tools: DD TD. Wrote the paper: MT. Provided pancreatic cancer expertise: DD TD.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0128814