Elevated background noise in adult attention deficit hyperactivity disorder is associated with inattention

• Published in: PloS one Vol. 10; no. 2; p. e0118271
• Main Authors: Bubl, Emanuel, Dörr, Michael, Riedel, Andreas, Ebert, Dieter, Philipsen, Alexandra, Bach, Michael, Tebartz van Elst, Ludger
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.02.2015; Public Library of Science (PLoS)
• Subjects: Adult; Adults; Analysis; Animal cognition; Attention - physiology; Attention Deficit Disorder with Hyperactivity - physiopathology; Attention Deficit Disorder with Hyperactivity - psychology; Attention deficit hyperactivity disorder; Autism; Background noise; Behavior modification; Case-Control Studies; Correlation analysis; Dopamine; Electroretinography - methods; Female; Humans; Hyperactivity; Information processing; Male; Medical diagnosis; Middle Aged; Noise; Noise - adverse effects; Noise measurement; Noise reduction; Patients; Psychiatry; Psychometrics; Psychotherapy; Retina; Signal processing; Surveys and Questionnaires; Therapeutic applications; Young Adult; Germany
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0118271

Inattention and distractibility are core symptoms of attention deficit hyperactivity disorder (ADHD). Still the neuronal organization is largely unknown. Previously we studied the electrophysiological activity of a distinct neuronal network-the retina-and found no change in stimulus-driven neural activity in patients with ADHD. However there is growing evidence for an elevated non stimulus-driven neural activity, or neuronal background noise, as underlying pathophysiological correlate. To further examine the biological bases that might underlie ADHD and problems with inattention, we performed a new analysis to test the hypothesis of an elevated background noise as underlying neuronal correlate for ADHD and problems with inattention in humans. A direct measure of background noise in patients with ADHD has not been described yet. The retinal background noise was assessed based on pattern electroretinogram (PERG) data in 20 unmedicated ADHD patients and 20 healthy controls. The PERG is an electrophysiological measure for retinal ganglion cell function. ADHD severity was assessed by interview and questionnaire. Noise amplitude was significantly higher (138%) in patients with ADHD compared to the control group (p = 0.0047). Noise amplitude correlated significantly with psychometric measures for ADHD (CAARS) especially inattention (r = 0.44, p = 0.004). The data provide evidence that an elevated background noise is associated with symptoms of inattention in ADHD and support the use of therapeutic interventions that reduce noise and distraction in patients with ADHD.