Incidence and geographical variation of amyotrophic lateral sclerosis (ALS) in Southern Germany--completeness of the ALS registry Swabia
Objective of this paper was to investigate the incidence, potential geographical clusters and the completeness of the amyotrophic lateral sclerosis (ALS) registry in Southern Germany (Swabia). Age-standardized incidence rates (ASR) and ratios (SIR) as well as 95% confidence intervals (CI) were estim...
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Published in | PloS one Vol. 9; no. 4; p. e93932 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Public Library of Science
01.04.2014
Public Library of Science (PLoS) |
Subjects | |
Online Access | Get full text |
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Summary: | Objective of this paper was to investigate the incidence, potential geographical clusters and the completeness of the amyotrophic lateral sclerosis (ALS) registry in Southern Germany (Swabia). Age-standardized incidence rates (ASR) and ratios (SIR) as well as 95% confidence intervals (CI) were estimated at county level. Capture-recapture (CARE) procedures were applied taking data source dependency into account to estimate the quality of case ascertainment in the ALS registry Swabia. We identified 438 ALS cases (53% men, 47% women) in the target population of about 8.4 Mio inhabitants. The gender ratio (men∶women) was 1.1∶1. The mean age at onset of ALS was 63.8 (SD = 11.9) years for men and 66.0 (12.2) for women. The age distribution peaked in the age group 70-74 years. The ASR of ALS was 2.5 per 100,000 person years (PY; 95% CI: 2.3-2.7). The mean SIR was 1.1 per 100,000 PY (95% CI: 1.0-1.2). High SIR suggesting geographical clusters were observed in two counties (Göppingen and Bodenseekreis), but the variation was not statistically significant (p-values = 0.2 and 0.5). The percentage of CARE estimated missing cases was 18.9% in the registry yielding an ASR of 3.1 per 100,000 PY. The high coverage of the CARE estimated completeness of the ALS registry Swabia indicates excellent quality for future projects. Regional variations have to be investigated further. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conceived and designed the experiments: AL GN. Performed the experiments: GN HU JK. Analyzed the data: GN HU JK. Wrote the paper: AL AR DR GN HU JK KG PW. Data collection: AL AR DR GN HU. Competing Interests: The authors have declared that no competing interests exist. Members of the ALS registry Study Group can be found in the acknowledgments. |
ISSN: | 1932-6203 1932-6203 |
DOI: | 10.1371/journal.pone.0093932 |