A global approach to describe retinal defocus patterns

The popularity of myopia treatments based on the peripheral defocus theory has risen. So far, little evidence has emerged around the questions which of these treatments are effective and why. In order to establish a framework that enables clinicians and researchers to acknowledge the possible intera...

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Published inPloS one Vol. 14; no. 4; p. e0213574
Main Authors García García, Miguel, Pusti, Dibyendu, Wahl, Siegfried, Ohlendorf, Arne
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 02.04.2019
Public Library of Science (PLoS)
Subjects
Adult
Algorithms
Biology and Life Sciences
Care and treatment
Contact lenses
Eye - pathology
Female
Fovea Centralis - physiopathology
Humans
Hyperopia
Hyperopia - pathology
Hyperopia - therapy
Lens, Crystalline - pathology
Male
Medicine and Health Sciences
Myopia
Myopia - pathology
Myopia - therapy
Optics
Physiology
Refractive errors
Retina
Retina - pathology
Social Sciences
Studies
Visual field
Visual fields
Germany
Spain
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Summary:The popularity of myopia treatments based on the peripheral defocus theory has risen. So far, little evidence has emerged around the questions which of these treatments are effective and why. In order to establish a framework that enables clinicians and researchers to acknowledge the possible interactions of different defocus patterns across the retina, different peripheral refractive errors (PRX) of subjects and different designs of optical treatments were evaluated. Dioptric defocus patterns on the retinal level have been obtained by merging the matrices of dioptric defocus maps of the visual field of different scenarios with individual peripheral refractive errors and different optical designs of multifocal contact lenses. The newly obtained matrices were statistically compared using a non-parametric test with familywise error algorithms and multi-comparison tests. Results show that asymmetric peripheral refractive error profiles (temporal or nasal positively skewed) appear to be less prone to be changed by the defocus imposition of multifocal contact lenses than those presenting symmetric patterns (relative peripheral myopia or hyperopia).
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Competing Interests: The authors declare that there are no conflicts of interest related to this article. This work was done in an industry-on-campus-cooperation between the University Tuebingen and Carl Zeiss Vision International GmbH. The work was supported by the European Grant Marie Sklodowska-Curie grant agreement No 675137. Authors MGG, AO & SW are employed by Carl Zeiss Vision International GmbH (E) and are scientists at the University Tuebingen. The author DP is employed (E) by the University of Murcia. According to the journal policy, they declare their employment positions. The authors acknowledge support by Deutsche Forschungsgemeinschaft and Open Access Publishing Fund of the University of Tübingen. This does not alter their adherence to PLOS ONE policies on sharing data and materials.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0213574