Tagged MEG measures binocular rivalry in a cortical network that predicts alternation rate

• Published in: PloS one Vol. 14; no. 7; p. e0218529
• Main Authors: Bock, Elizabeth A., Fesi, Jeremy D., Baillet, Sylvain, Mendola, Janine D.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.07.2019; Public Library of Science (PLoS)
• Subjects: Adult; Alternations; Binocular vision; Biology and Life Sciences; Brain; Brain mapping; Cerebral Cortex - physiology; Cerebral dominance; Coding; Competition; Cortex (occipital); Cortex (parietal); Cortex (temporal); Dominance; Eye; Female; Flicker; Humans; Intermodulation; Magnetoencephalography; Male; Medical imaging; Medicine and Health Sciences; Methods; Models, Neurological; Nerve Net - physiology; Neural coding; Neuroimaging; Neurons; Neurophysiology; Neurosurgery; Novels; Ocular dominance; Photic Stimulation; Physiological aspects; Research and Analysis Methods; Social Sciences; Switches; Temporal lobe; Vision, Binocular - physiology; Vision, Monocular - physiology; Visual cortex; Visual perception; Visual stimuli; Canada; Montreal Quebec Canada; Quebec Canada
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0218529

Binocular rivalry (BR) is a dynamic visual illusion that provides insight into the cortical mechanisms of visual awareness, stimulus selection, and object identification. When dissimilar binocular images cannot be fused, perception switches every few seconds between the left and right eye images. The speed at which individuals switch between alternatives is a stable, partially heritable trait. In order to isolate the monocular and binocular processes that determine the speed of rivalry, we presented stimuli tagged with a different flicker frequency in each eye and applied stimulus-phase locked MEG source imaging. We hypothesized that the strength of the evoked fundamental or intermodulation frequencies would vary when comparing Fast and Slow Switchers. Ten subjects reported perceptual alternations, with mean dominance durations between 1.2-4.0 sec. During BR, event-related monocular input in V1, and broadly in higher-tier ventral temporal cortex, waxed and waned with the periods of left or right eye dominance/suppression. In addition, we show that Slow Switchers produce greater evoked intermodulation frequency responses in a cortical network composed of V1, lateral occipital, posterior STS, retrosplenial & superior parietal cortices. Importantly, these dominance durations were not predictable from the brain responses to either of the fundamental tagging frequencies in isolation, nor from any responses to a pattern rivalry control condition, or a non-rivalrous control. The novel cortical network isolated, which overlaps with the default-mode network, may contain neurons that compute the level of endogenous monocular difference, and monitor accumulation of this conflict over extended periods of time. These findings are the first to relate the speed of rivalry across observers to the 'efficient coding' theory of computing binocular differences that may apply to binocular vision generally.