A Bayesian meta-analysis on prevalence of hepatitis B virus infection among Chinese volunteer blood donors

• Published in: PloS one Vol. 8; no. 11; p. e79203
• Main Authors: Liu, Guang-cong, Sui, Guo-yuan, Liu, Guang-ying, Zheng, Yang, Deng, Yan, Gao, Yan-yan, Wang, Lie
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.11.2013; Public Library of Science (PLoS)
• Subjects: Analysis; Bayes Theorem; Bayesian analysis; Blood; Blood & organ donations; Blood donation; Blood Donors; Blood transfusion; China; Disease transmission; Donors (electronic); Epidemiology; Geography; Health aspects; Hepatitis; Hepatitis B; Hepatitis B - epidemiology; Hepatitis B surface antigen; Hepatitis B virus; HIV; Human immunodeficiency virus; Humans; Infection; Infections; Medical research; Meta-analysis; Online searching; Prevalence; Public health; Regression analysis; Safety; Sample size; Studies; Subgroups; Transfusion; Trends; Viral infections; Viruses; Websites; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0079203

Although transfusion-transmitted infection of hepatitis B virus (HBV) threatens the blood safety of China, the nationwide circumstance of HBV infection among blood donors is still unclear. To comprehensively estimate the prevalence of HBsAg positive and HBV occult infection (OBI) among Chinese volunteer blood donors through bayesian meta-analysis. We performed an electronic search in Pub-Med, Web of Knowledge, Medline, Wanfang Data and CNKI, complemented by a hand search of relevant reference lists. Two authors independently extracted data from the eligible studies. Then two bayesian random-effect meta-analyses were performed, followed by bayesian meta-regressions. 5957412 and 571227 donors were identified in HBsAg group and OBI group, respectively. The pooled prevalence of HBsAg group and OBI group among donors is 1.085% (95% credible interval [CI] 0.859%~1.398%) and 0.094% (95% CI 0.0578%~0.1655%). For HBsAg group, subgroup analysis shows the more developed area has a lower prevalence than the less developed area; meta-regression indicates there is a significant decreasing trend in HBsAg positive prevalence with sampling year (beta = -0.1202, 95% -0.2081~-0.0312). Blood safety against HBV infection in China is suffering serious threats and the government should take effective measures to improve this situation.