Smoking fewer than 20 cigarettes per day and remaining abstinent for more than 12 hours reduces carboxyhemoglobin levels in packed red blood cells for transfusion

• Published in: PloS one Vol. 13; no. 9; p. e0204102
• Main Authors: Boehm, Renata E, Arbo, Bruno D, Leal, Denise, Hansen, Alana W, Pulcinelli, Rianne R, Thiesen, Flávia V, Balsan, Almeri M, Onsten, Tor G H, Gomez, Rosane
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.09.2018; Public Library of Science (PLoS)
• Subjects: Abstinence; Analysis; Angina pectoris; Biology and Life Sciences; Blood; Blood & organ donations; Blood banks; Blood cells; Blood donation; Blood donors; Blood transfusion; Blood transfusions; Carbon monoxide; Carboxyhemoglobin; Cigarette smoke; Cigarettes; Cocaine; Comparative analysis; Erythrocytes; Health sciences; Hematocrit; Hematology; Hemoglobin; Hemolysis; Hospitals; Medicine and Health Sciences; Nicotine; Observational studies; Outdoor air quality; Parameters; Pharmacology; Pharmacy; Public health; Quality control; Red blood cells; Risk reduction; Smoke; Smoking; Studies; Tobacco; Transfusion; Brazil; Rio Grande do Sul Brazil; United States > US
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0204102

The prevalence of smokers among blood donors and the effect of smoking on the quality of donated blood have not been extensively explored. In the present study, we determined the prevalence of smoker donors in a large blood bank in Southern Brazil and evaluated the quality of packed red blood cells (RBCs) from these donors through recommended quality control tests and measurement of carboxyhemoglobin (COHb) levels. We then assessed the influence of smoking habits and abstinence before donation on these parameters. An observational study was conducted to determine the prevalence of smoking donors, while a prospective cohort study compared conventional hematological and serological parameters and COHb levels at 0, 15, and 30 days after donation in RBCs donated by smokers (N = 31) and nonsmokers (N = 31) and their association with smoking habits and abstinence before donation. Of 14,428 blood donations received in 1 year, 5.9% were provided by smokers. Storage over time slightly altered some quality parameters, such as hematocrit, hemoglobin, hemolysis, and COHb levels, in RBC packs. COHb levels were higher in RBC packs from smokers (8%) than from non-smokers (2%), and increased as a function of the number of cigarettes smoked daily and time elapsed since the last cigarette smoked before donation. Lower levels were found in RBC packs from donors who smoked fewer than 20 cigarettes per day or remained abstinent for more than 12h before giving blood. Although cigarette smoke had no significant effect on blood quality parameters such as hematocrit, hemoglobin, or hemolysis, it quadrupled COHb levels in packed RBCs. Abstinence from smoking for more than 12h or smoking fewer than 20 cigarettes daily helped decrease COHb levels. Given the increasing prevalence of tobacco use worldwide, we suggest blood banks recommend 12h of tobacco abstinence before donation and analyze COHb levels in donated blood as an approach to reduce risk for high-risk recipients.