Seroprevalence of SARS-CoV-2 specific IgG antibodies in District Srinagar, northern India - A cross-sectional study

• Published in: PloS one Vol. 15; no. 11; p. e0239303
• Main Authors: Khan, S Muhammad Salim, Qurieshi, Mariya Amin, Haq, Inaamul, Majid, Sabhiya, Bhat, Arif Akbar, Nabi, Sahila, Ganai, Nisar Ahmad, Zahoor, Nazia, Nisar, Auqfeen, Chowdri, Iqra Nisar, Qazi, Tanzeela Bashir, Kousar, Rafiya, Lone, Abdul Aziz, Sabah, Iram, Nabi, Shahroz, Sumji, Ishtiyaq Ahmad, Kawoosa, Misbah Ferooz, Ayoub, Shifana
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.11.2020; Public Library of Science (PLoS)
• Subjects: Adult; Adults; Age; Aged; Antibodies; Antibodies, Viral - blood; Asymptomatic; Betacoronavirus - genetics; Betacoronavirus - immunology; Betacoronavirus - isolation & purification; Biochemistry; Biology and life sciences; Chemiluminescence; Comorbidity; Coronavirus Infections - diagnosis; Coronavirus Infections - epidemiology; Coronavirus Infections - virology; Coronaviruses; COVID-19; Cross-Sectional Studies; Disease control; Disease transmission; Distribution; Female; Hospitals; Humans; Immunoassay; Immunoglobulin G; Immunoglobulin G - blood; India - epidemiology; Infections; Influenza; Laboratories; Male; Medical schools; Medicine; Medicine and health sciences; Microparticles; Middle Aged; Mitigation; Odds Ratio; Pandemics; Physiological aspects; Pneumonia, Viral - diagnosis; Pneumonia, Viral - epidemiology; Pneumonia, Viral - virology; Population; Psychological aspects; Public health; Research and Analysis Methods; RNA, Viral - genetics; RNA, Viral - metabolism; Sample size; SARS-CoV-2; Serology; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Signs and symptoms; Software; Supervision; Vaccines; Viral diseases; India; Kashmir India
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0239303

Prevalence of IgG antibodies against SARS-CoV-2 infection provides essential information for deciding disease prevention and mitigation measures. We estimate the seroprevalence of SARS-CoV-2 specific IgG antibodies in District Srinagar. 2906 persons >18 years of age selected from hospital visitors across District Srinagar participated in the study. We tested samples for the presence of SARS-CoV-2 specific IgG antibodies using a chemiluminescent microparticle immunoassay-based serologic test. Age- and gender-standardized seroprevalence was 3.6% (95% CI 2.9% to 4.3%). Age 30-69 years, a recent history of symptoms of an influenza-like-illness, and a history of being placed under quarantine were significantly related to higher odds of the presence of SARS-CoV-2 specific IgG antibodies. The estimated number of SARS-CoV-2 infections during the two weeks preceding the study, adjusted for test performance, was 32602 with an estimated (median) infection-to-known-case ratio of 46 (95% CI 36 to 57). The seroprevalence of SARS-CoV-2 specific IgG antibodies is low in the District. A large proportion of the population is still susceptible to the infection. A sizeable number of infections remain undetected, and a substantial proportion of people with symptoms compatible with COVID-19 are not tested.