The Study of Quality Evaluation of A Hand Rub (Hand Sanitizer) With Who-Based-Standard Formulation and Percent Reduction of Bacteria (Percentage Kill Bacteria) In Methicillin-Resistant Staphylococcus Aureus (MRSA)

• Published in: Indonesian Journal of Pharmacy (2013)
• Main Authors: Subhan, Ahmad, Manalu, Wasmen, Rahminiwati, Min, Darusman, Huda Salahudin
• Format: Journal Article
• Language: English
• Published: 27.01.2021
• ISSN: 2338-9427; 2338-9427
• DOI: 10.22146/ijp.1252

The pandemic that occurred caused both by COVID-19 (currently occurring), as well as the clone of the methicillin-resistant staphylococcus aureus (MRSA) in the previous period, has really threatened human life. This condition requires materials that can break the chain of transmission from human to human and the environment to human. This study aimed to evaluate the quality of alcohol-based hand rub with WHO-based-standard formulation based on the stability of the formulation, the risk of irritation, and the ability to kill bacteria. Assessment on the presence of rancidity, clarity, discoloration, final alcohol content, and skin irritation risk was done to know the quality of product formulation. A bacterial Methicillin resistance staphylococcus aureus (MRSA) was used to assess the percentage of bacterial killing power. The selected bacteria were bacteria commonly found in the hospital environment. The results of formulation stability from four variants of level modification showed that MK.IV has good stability compared to other formulation modifications. In terms of irritation risk, twenty-three selected subjects were generally well tolerated in use. The results of the percentage kill test against MRSA showed that the percentage kill is 99.90% at 1st, 2nd, and 5th minute. The selected manufacturer's product also showed the same percentage kill value at the 1st, 2nd, and 5th minute. The results of the percentage kill test showed that the effective value for each contact time is ≥ 90%.