Low-density Lipoprotein Cholesterol/High-density Lipoprotein Cholesterol Ratio as Predictor of First Acute Myocardial Infarction and Major Adverse Cardiovascular Event after Intervention in Young Males

• Published in: Chinese medical journal Vol. 131; no. 18; pp. 2239 - 2241
• Main Authors: Li, Zhao, Wen, Shao-Jun, Li, Zhi-Zhong, Li, Nan, Huang, Ji
• Format: Journal Article
• Language: English
• Published: China Wolters Kluwer India Pvt. Ltd 20.09.2018; Medknow Publications and Media Pvt. Ltd; Lippincott Williams & Wilkins Ovid Technologies; Department of Hypertension Research, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Disease, Capital University of Medical Sciences, Beijing 100029, China%Department of Hypertension Research, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Disease, Capital University of Medical Sciences, Beijing 100029, China; Department of Cardiology, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing 100029, China%Department of Cardiology, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing 100029, China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer
• Subjects: Adolescent; Adult; Age; Cardiovascular disease; Case-Control Studies; Cholesterol; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Confidence Intervals; Coronary vessels; Correspondence; Diabetes; Family medical history; Female; Heart attacks; Hospitalization; Humans; Hypertension; Insulin resistance; Intervention; Lipids; Low density lipoprotein; Male; Males; Medical imaging; Medical prognosis; Metabolic syndrome; Myocardial Infarction - blood; Myocardial Infarction - epidemiology; Odds Ratio; Ratios; Regression analysis; Risk Factors; ST Elevation Myocardial Infarction - blood; ST Elevation Myocardial Infarction - epidemiology; Young Adult; Beijing China; @@
• ISSN: 0366-6999; 2542-5641
• DOI: 10.4103/0366-6999.240803

According to ROC analysis, LDL-C/HDL-C ratio could be used to predict AMI with an area under the curve (AUC) of 0.646 (95% CI: 0.589–0.693; P < 0.001). Step-wise multivariable logistic regression analysis indicated that decreased HDL-C (P < 0.001; OR = 0.049; 95% CI: 0.012–0.200) and high LDL-C (P < 0.001; OR = 5.459; 95% CI: 2.828–10.537) were the risk factors indicating multi-vessel lesions. [...]this study found that LDL-C/HDL-C ratio was a strong risk factor for AMI and prognostic factor for MACE. [...]non-lipid ASCVD risk factors should also be managed appropriately, particularly hypertension, smoking, and diabetes mellitus in young males. [...]we enrolled 267 young male patients with AMI and 247 age-matched controls and found that LDL-C/HDL-C ratio was the strongest risk factor associated with AMI.