Association between early promoter-specific DNA methylation changes and outcome in older acute myeloid leukemia patients

Highlights • Very early peripheral blood promoter demethylation of some genes predict response. • Global DNA methylation decreased by one month in older AML patients on treatment. • Early methylation tests could help determine appropriate older AML therapy choice.

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Bibliographic Details
Published inLeukemia research Vol. 42; pp. 68 - 74
Main Authors Achille, Nicholas J, Othus, Megan, Phelan, Kathleen, Zhang, Shubin, Cooper, Kathrine, Godwin, John E, Appelbaum, Frederick R, Radich, Jerald P, Erba, Harry P, Nand, Sucha, Zeleznik-Le, Nancy J
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.03.2016
Subjects
Aged
Aminoglycosides - administration & dosage
Aminoglycosides - adverse effects
AML
Antibodies, Monoclonal, Humanized - administration & dosage
Antibodies, Monoclonal, Humanized - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Azacitidine - administration & dosage
Azacitidine - adverse effects
Decitabine
DNA methylation
DNA Methylation - genetics
Elderly
Enzyme-Linked Immunosorbent Assay
Female
Hematology, Oncology and Palliative Medicine
Humans
Hydroxyurea - administration & dosage
Hydroxyurea - adverse effects
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - genetics
Male
Middle Aged
Prognosis
Prognostic
Promoter Regions, Genetic - genetics
Real-Time Polymerase Chain Reaction
Risk Factors
Transcriptome
Treatment Outcome
AML
DNA methylation
Decitabine
Elderly
Prognostic
Online AccessGet full text

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More Information
Summary:Highlights • Very early peripheral blood promoter demethylation of some genes predict response. • Global DNA methylation decreased by one month in older AML patients on treatment. • Early methylation tests could help determine appropriate older AML therapy choice.
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ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2016.01.004