Noise Amplification in Human Tumor Suppression following Gamma Irradiation

• Published in: PloS one Vol. 6; no. 8; p. e22487
• Main Authors: Liu, Bo, Yan, Shiwei, Gao, Xingfa
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.08.2011; Public Library of Science (PLoS)
• Subjects: Amplification; Analysis; Biology; Cancer; Cell Line, Tumor; Chemical reactions; Computer Science; External stimuli; Fourier Analysis; Frequency domain analysis; Gamma irradiation; Gamma Rays; High energy physics; Humans; Irradiation; Laboratories; Mathematics; Models, Theoretical; Nanomaterials; Noise; Ordinary differential equations; Partial differential equations; Physics; Probability distribution; Proto-Oncogene Proteins c-mdm2 - metabolism; Telecommunications systems; Tumor proteins; Tumor suppression; Tumor Suppressor Protein p53 - metabolism; Tumors; Beijing China; China

The influence of noise on oscillatory motion is a subject of permanent interest, both for fundamental and practical reasons. Cells respond properly to external stimuli by using noisy systems. We have clarified the effect of intrinsic noise on the dynamics in the human cancer cells following gamma ir...