Noise Amplification in Human Tumor Suppression following Gamma Irradiation

The influence of noise on oscillatory motion is a subject of permanent interest, both for fundamental and practical reasons. Cells respond properly to external stimuli by using noisy systems. We have clarified the effect of intrinsic noise on the dynamics in the human cancer cells following gamma ir...

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Bibliographic Details
Published inPloS one Vol. 6; no. 8; p. e22487
Main Authors Liu, Bo, Yan, Shiwei, Gao, Xingfa
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 05.08.2011
Public Library of Science (PLoS)
Subjects
Amplification
Analysis
Biology
Cancer
Cell Line, Tumor
Chemical reactions
Computer Science
External stimuli
Fourier Analysis
Frequency domain analysis
Gamma irradiation
Gamma Rays
High energy physics
Humans
Irradiation
Laboratories
Mathematics
Models, Theoretical
Nanomaterials
Noise
Ordinary differential equations
Partial differential equations
Physics
Probability distribution
Proto-Oncogene Proteins c-mdm2 - metabolism
Telecommunications systems
Tumor proteins
Tumor suppression
Tumor Suppressor Protein p53 - metabolism
Tumors
Beijing China
China
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Summary:The influence of noise on oscillatory motion is a subject of permanent interest, both for fundamental and practical reasons. Cells respond properly to external stimuli by using noisy systems. We have clarified the effect of intrinsic noise on the dynamics in the human cancer cells following gamma irradiation. It is shown that the large amplification and increasing mutual information with delay are due to coherence resonance. Furthermore, frequency domain analysis is used to study the mechanisms.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Conceived and designed the experiments: BL SY. Performed the experiments: BL. Analyzed the data: BL SY. Contributed reagents/materials/analysis tools: BL SY XG. Wrote the paper: BL SY XG.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0022487