Noise Amplification in Human Tumor Suppression following Gamma Irradiation

The influence of noise on oscillatory motion is a subject of permanent interest, both for fundamental and practical reasons. Cells respond properly to external stimuli by using noisy systems. We have clarified the effect of intrinsic noise on the dynamics in the human cancer cells following gamma ir...

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Published inPloS one Vol. 6; no. 8; p. e22487
Main Authors Liu, Bo, Yan, Shiwei, Gao, Xingfa
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 05.08.2011
Public Library of Science (PLoS)
Subjects
Amplification
Analysis
Biology
Cancer
Cell Line, Tumor
Chemical reactions
Computer Science
External stimuli
Fourier Analysis
Frequency domain analysis
Gamma irradiation
Gamma Rays
High energy physics
Humans
Irradiation
Laboratories
Mathematics
Models, Theoretical
Nanomaterials
Noise
Ordinary differential equations
Partial differential equations
Physics
Probability distribution
Proto-Oncogene Proteins c-mdm2 - metabolism
Telecommunications systems
Tumor proteins
Tumor suppression
Tumor Suppressor Protein p53 - metabolism
Tumors
Beijing China
China
Online AccessGet full text
ISSN1932-6203
1932-6203
DOI10.1371/journal.pone.0022487

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Abstract The influence of noise on oscillatory motion is a subject of permanent interest, both for fundamental and practical reasons. Cells respond properly to external stimuli by using noisy systems. We have clarified the effect of intrinsic noise on the dynamics in the human cancer cells following gamma irradiation. It is shown that the large amplification and increasing mutual information with delay are due to coherence resonance. Furthermore, frequency domain analysis is used to study the mechanisms.
AbstractList The influence of noise on oscillatory motion is a subject of permanent interest, both for fundamental and practical reasons. Cells respond properly to external stimuli by using noisy systems. We have clarified the effect of intrinsic noise on the dynamics in the human cancer cells following gamma irradiation. It is shown that the large amplification and increasing mutual information with delay are due to coherence resonance. Furthermore, frequency domain analysis is used to study the mechanisms.
The influence of noise on oscillatory motion is a subject of permanent interest, both for fundamental and practical reasons. Cells respond properly to external stimuli by using noisy systems. We have clarified the effect of intrinsic noise on the dynamics in the human cancer cells following gamma irradiation. It is shown that the large amplification and increasing mutual information with delay are due to coherence resonance. Furthermore, frequency domain analysis is used to study the mechanisms.The influence of noise on oscillatory motion is a subject of permanent interest, both for fundamental and practical reasons. Cells respond properly to external stimuli by using noisy systems. We have clarified the effect of intrinsic noise on the dynamics in the human cancer cells following gamma irradiation. It is shown that the large amplification and increasing mutual information with delay are due to coherence resonance. Furthermore, frequency domain analysis is used to study the mechanisms.
Audience Academic
Author Gao, Xingfa
Liu, Bo
Yan, Shiwei
AuthorAffiliation 1 Key Laboratory of Beam Technology and Material Modification of Ministry of Education, College of Nuclear Science and Technology, Beijing Normal University, Beijing, China
2 Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China
University of Maribor, Slovenia
3 Beijing Radiation Center, Beijing, China
AuthorAffiliation_xml – name: University of Maribor, Slovenia
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– name: 1 Key Laboratory of Beam Technology and Material Modification of Ministry of Education, College of Nuclear Science and Technology, Beijing Normal University, Beijing, China
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  surname: Liu
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  surname: Yan
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/21850227$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_1021_acs_jpclett_4c02382
crossref_primary_10_1093_imammb_dqv002
crossref_primary_10_1371_journal_pone_0077570
crossref_primary_10_1007_s11467_017_0667_9
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2011 Liu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Liu et al. 2011
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Conceived and designed the experiments: BL SY. Performed the experiments: BL. Analyzed the data: BL SY. Contributed reagents/materials/analysis tools: BL SY XG. Wrote the paper: BL SY XG.
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Snippet The influence of noise on oscillatory motion is a subject of permanent interest, both for fundamental and practical reasons. Cells respond properly to external...
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SourceType Open Website
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StartPage e22487
SubjectTerms Amplification
Analysis
Biology
Cancer
Cell Line, Tumor
Chemical reactions
Computer Science
External stimuli
Fourier Analysis
Frequency domain analysis
Gamma irradiation
Gamma Rays
High energy physics
Humans
Irradiation
Laboratories
Mathematics
Models, Theoretical
Nanomaterials
Noise
Ordinary differential equations
Partial differential equations
Physics
Probability distribution
Proto-Oncogene Proteins c-mdm2 - metabolism
Telecommunications systems
Tumor proteins
Tumor suppression
Tumor Suppressor Protein p53 - metabolism
Tumors
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Title Noise Amplification in Human Tumor Suppression following Gamma Irradiation
URI https://www.ncbi.nlm.nih.gov/pubmed/21850227
https://www.proquest.com/docview/1306908440
https://www.proquest.com/docview/884424808
https://pubmed.ncbi.nlm.nih.gov/PMC3151249
https://doaj.org/article/513b8ffd630f4dcb99c74779a66434fd
http://dx.doi.org/10.1371/journal.pone.0022487
Volume 6
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