Lactosucrose inhibits body fat accumulation in rats by decreasing intestinal lipid absorption

• Published in: Bioscience, biotechnology, and biochemistry Vol. 73; no. 3; pp. 582 - 587
• Main Authors: Mizote, A.(Hayashibara Biochemical Labs. Inc., Okayama (Japan). Research Center), Taniguchi, Y, Takei, Y, Koya Miyata, S, Kohno, K, Iwaki, K, Kurose, M, Oku, K, Chaen, H, Fukuda, S
• Format: Journal Article
• Language: English
• Published: Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 23.03.2009; Japan Society for Bioscience Biotechnology and Agrochemistry; Oxford University Press
• Subjects: Abdominal Fat - drug effects; Abdominal Fat - metabolism; ACIDE GRAS; ACIDOS GRASOS; ADIPOSE TISSUE; Adipose Tissue - drug effects; Adipose Tissue - metabolism; Animals; Biological and medical sciences; BLOOD SERUM; Dietary Supplements; ESTERASAS; ESTERASE; ESTERASES; FATTY ACIDS; Fatty Acids, Nonesterified - blood; Fundamental and applied biological sciences. Psychology; INHIBICION; INHIBITION; INTESTIN; Intestinal Absorption - drug effects; INTESTINES; INTESTINOS; lactosucrose; Lipase - metabolism; Lipid Metabolism - drug effects; Male; Obesity - prevention & control; OLIGOSACARIDOS; OLIGOSACCHARIDE; OLIGOSACCHARIDES; PANCREAS; Pancreas - enzymology; RAT; RATA; RATS; Rats, Wistar; SERUM SANGUIN; SUERO SANGUINEO; TEJIDO ADIPOSO; Time Factors; TISSU ADIPEUX; TRIGLICERIDOS; TRIGLYCERIDE; TRIGLYCERIDES; Triglycerides - blood; Triolein - metabolism; Trisaccharides - metabolism; Trisaccharides - pharmacology; Veins - drug effects; Veins - metabolism; Adipose tissue; Rat; Oligosaccharide; lactosucrose; Rodentia; Gut; Lipids; Accumulation; Vertebrata; Mammalia; Absorption; Fat; Inhibition
• ISSN: 0916-8451; 1347-6947
• DOI: 10.1271/bbb.80658

Lactosucrose (LS, 4 G -β-D-galactosylsucrose) is a non-digestible oligosaccharide, and the consumption of LS selectively increases the proportion of intestinal bifidobacteria. We examined in this study the hypolipidemic potential of LS. An oral triolein tolerance test on rats indicated that LS reduced the elevation of serum triglyceride (TG) and free fatty acids (FFA). Furthermore, LS inhibited the enzymatic digestion of triolein by pancreatic lipase in vitro. NMR spectroscopy showed that LS formed an intermolecular complex with triolein. The long-term consumption of a diet containing 5% LS for 8 weeks significantly decreased the weight of abdominal adipose tissue when compared with that of the control group. Thus, LS may reduce adipose tissue accumulation by inhibiting intestinal lipid absorption via a direct interaction with TG.