Insulin Resistance in Non-Obese Subjects Is Associated with Activation of the JNK Pathway and Impaired Insulin Signaling in Skeletal Muscle

• Published in: PloS one Vol. 6; no. 5; p. e19878
• Main Authors: Masharani, Umesh B., Maddux, Betty A., Li, Xiaojuan, Sakkas, Giorgos K., Mulligan, Kathleen, Schambelan, Morris, Goldfine, Ira D., Youngren, Jack F.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.05.2011; Public Library of Science (PLoS)
• Subjects: Activation; Adult; Biology; Dual energy X-ray absorptiometry; Enzyme Activation; Female; Glucose; Humans; Insulin; Insulin - metabolism; Insulin receptor substrate 1; Insulin Resistance; JNK protein; Kinases; Lipids; Magnetic resonance imaging; Male; MAP kinase; MAP Kinase Kinase 4 - metabolism; Medicine; Muscle, Skeletal - metabolism; Obesity; Pathogenesis; Phosphorylation; Phosphotransferases; Physical fitness; Proteins; Serine; Signal Transduction; Signaling; Skeletal muscle; Stress; Stresses; Tissues; Type 2 diabetes; Tyrosine; United States > US; San Francisco California; California
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0019878

The pathogenesis of insulin resistance in the absence of obesity is unknown. In obesity, multiple stress kinases have been identified that impair the insulin signaling pathway via serine phosphorylation of key second messenger proteins. These stress kinases are activated through various mechanisms r...