The therapeutic potential of bone marrow mesenchymal stem cells in premature ovarian failure

• Published in: Stem cell research & therapy Vol. 9; no. 1; p. 263
• Main Authors: He, Yantao, Chen, Dongmei, Yang, Lingling, Hou, Qiaoni, Ma, Huiming, Xu, Xian
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.10.2018; BioMed Central; BMC
• Subjects: Amenorrhea; Angiogenesis; Animals; Apoptosis; Bone marrow; Bone marrow cells; Bone Marrow Cells - cytology; Bone Marrow Cells - physiology; Bone marrow mesenchymal stem cells; Care and treatment; Cell Movement; Chemotherapy; Clinical trials; Cytokines; Cytokines - biosynthesis; Cytokines - genetics; Female; Gene expression; Growth factors; Health aspects; Humans; Immunoregulation; Infertility; Inflammation; Intercellular Signaling Peptides and Proteins - biosynthesis; Intercellular Signaling Peptides and Proteins - genetics; Laparoscopy; Menstrual Cycle - physiology; Menstruation; Mesenchymal Stem Cell Transplantation; Mesenchymal stem cells; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - physiology; Mesenchyme; Neovascularization, Physiologic; Osteoporosis; Ovarian diseases; Ovary - metabolism; Ovary - pathology; Oxidative stress; Paracrine Communication; Paracrine signalling; Premature ovarian failure; Primary Ovarian Insufficiency - genetics; Primary Ovarian Insufficiency - metabolism; Primary Ovarian Insufficiency - pathology; Primary Ovarian Insufficiency - therapy; Regenerative medicine; Regenerative Medicine - methods; Reproductive status; Review; Stem cell transplantation; Stem cells; Studies; Transplantation; Transplants & implants; Womens health; Bone marrow mesenchymal stem cells; Premature ovarian failure; Transplantation
• ISSN: 1757-6512; 1757-6512
• DOI: 10.1186/s13287-018-1008-9

With the development of regenerative medicine, a variety of mesenchymal stem cells (MSCs) are increasingly considered for the treatment of premature ovarian failure (POF). Reportedly, bone marrow-derived MSCs (BMSCs) improve the ovarian reserve, which mainly depends on homing and paracrine activities. Furthermore, paracrine factors secreted by these stem cells play an important role in ovarian recovery. Relevant studies indicate that BMSC transplantation has some positive effects on the treatment of POF in animals, but BMSCs are not widely applied in clinical therapy. Clinical trials are ongoing despite the fact that several patients experiencing BMSC transplantation recover their normal menstrual cycles and even give birth to babies. In this review, we discuss the possible therapeutic mechanisms of BMSCs for POF, migration, antiapoptosis, antifibrosis, angiogenesis, anti-inflammation, immunoregulation, and oxidative stress, which provide the theoretical basis for further study and clinical therapy.