Effects of acetate on lipid metabolism in muscles and adipose tissues of type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OKETF) rats

• Published in: Bioscience, biotechnology, and biochemistry Vol. 73; no. 3; pp. 570 - 576
• Main Authors: Yamashita, H.(Okayama Prefectural Univ., Soja (Japan). Faculty of Health and Welfare Science), Maruta, H, Jozuka, M, Kimura, R, Iwabuchi, H, Yamato, M, Saito, T, Fujisawa, K, Takahashi, Y, Kimoto, M, Hiemori, M, Tsuji, H
• Format: Journal Article
• Language: English
• Published: Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 23.03.2009; Japan Society for Bioscience Biotechnology and Agrochemistry; Oxford University Press
• Subjects: Abdominal Muscles - drug effects; Abdominal Muscles - metabolism; ACETATE; ACETATES; Acetates - pharmacology; ACETATOS; Adenosine Monophosphate - metabolism; Adenosine Triphosphate - metabolism; Adipocytes, Brown - drug effects; Adipocytes, Brown - metabolism; Adipocytes, White - drug effects; Adipocytes, White - metabolism; ADIPOSE TISSUE; Adipose Tissue - drug effects; Adipose Tissue - metabolism; AMP-Activated Protein Kinases - metabolism; Animals; Biological and medical sciences; DIABETE; DIABETES; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Energy Metabolism - drug effects; Fundamental and applied biological sciences. Psychology; GENE; Gene Expression Regulation - drug effects; GENES; Glucose Transporter Type 4 - genetics; lipid metabolism; Lipid Metabolism - drug effects; LIPIDE; LIPIDOS; LIPIDS; Male; METABOLISM; METABOLISME; METABOLISMO; MUSCLE; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; MUSCLES; MUSCULOS; Myoglobin - genetics; obesity; Otsuka Long-Evans Tokushima Fatty (OLETF) rats; OVERWEIGHT; Oxygen - metabolism; Phosphorylation - drug effects; RAT; RATA; RATS; Rats, Inbred OLETF; RNA, Messenger - genetics; RNA, Messenger - metabolism; SOBREPESO; SURPOIDS; TEJIDO ADIPOSO; TISSU ADIPEUX; TRANSCRIPCION; TRANSCRIPTION; Type 2 diabetes; Obesity; Adipose tissue; Rat; Rodentia; lipid metabolism; Lipids; Acetate; Metabolism; Otsuka Long-Evans Tokushima Fatty (OLETF) rats; Vertebrata; Mammalia; Muscle
• ISSN: 0916-8451; 1347-6947
• DOI: 10.1271/bbb.80634

We have reported that orally administrated acetate contributed to suppression of lipogenesis in the liver and to reduction of lipid accumulation in the adipose tissue of Otsuka Long-Evans Tokushima Fatty (OLETF) rats. The aim of this study was to investigate the effect of acetate on skeletal muscle and adipose tissues. Treatment with acetate showed a higher rate of oxygen consumption and a smaller size of lipid droplets in white adipose and brown adipose tissues. An analysis by Northern blotting revealed that the transcripts of myoglobin and Glut4 genes in the abdominal muscle of the OLETF rats were increased by acetate treatment, while the transcripts of lipolytic genes increased in the white adipose and brown adipose tissues. It is possible that acetate has effects on lipid metabolism in the skeletal muscles and the adipose tissues, and has functions that work against obesity and obesity-linked type 2 diabetes.