Meta-Analysis of the Significance of Asymptomatic Bacteriuria in Diabetes

• Published in: Diabetes care Vol. 34; no. 1; pp. 230 - 235
• Main Authors: Renko, Marjo, Tapanainen, Päivi, Tossavainen, Päivi, Pokka, Tytti, Uhari, Matti
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.01.2011
• Subjects: Adolescent; adolescents; Adult; Aged; Albuminuria; Albuminuria - epidemiology; Bacteria; Bacteriuria; Bacteriuria - epidemiology; Biological and medical sciences; children; Clinical trials; Diabetes; Diabetes Mellitus; Diabetes Mellitus - epidemiology; Diabetes therapy; Diabetes. Impaired glucose tolerance; Diabetics; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; epidemiology; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Humans; insulin-dependent diabetes mellitus; Male; Medical sciences; men; Meta-analysis; Metabolic diseases; Middle Aged; Miscellaneous; noninsulin-dependent diabetes mellitus; odds ratio; patients; Public health. Hygiene; Public health. Hygiene-occupational medicine; Reviews/Commentaries/ADA Statements; Studies; systematic review; Type 2 diabetes; urinary tract diseases; Women; Young Adult; Endocrinopathy; Human; Bacteriuria; Nutrition; Diabetes mellitus; Evidence-based practice; Metabolic diseases; Asymptomatic; Evidence-based medicine; Endocrinology; Metaanalysis
• ISSN: 0149-5992; 1935-5548; 1935-5548
• DOI: 10.2337/dc10-0421

OBJECTIVE: To evaluate whether asymptomatic bacteriuria (ASB) is more common in patients with diabetes than among control subjects. In addition, we wanted to clarify the clinical significance of ASB in patients with diabetes. RESEARCH DESIGN AND METHODS: We conducted a systematic review and meta-analysis of published data since 1966. Twenty-two studies fulfilled the inclusion criteria of the meta-analysis. RESULTS: ASB was present in 439 of 3,579 (12.2%) patients with diabetes and in 121 of 2,702 (4.5%) healthy control subjects. ASB was more common both in patients with type 1 diabetes (odds ratio 3.0 [95% CI 1.1-8.0]) and type 2 diabetes (3.2 [2.0-5.2]) than in control subjects. The point prevalence of ASB was higher in both women (14.2 vs. 5.1%; 2.6 [1.6-4.1]) and men (2.3 vs. 0.8%; 3.7 [1.3-10.2]) as well as in children and adolescents (12.9 vs. 2.7%; 5.4 [2.7-11.0]) with diabetes than in healthy control subjects. Albuminuria was more common in patients with diabetes and ASB than those without ASB (2.9 [1.7-4.8]). History of urinary tract infections was associated with ASB (1.6 [1.1-2.3]). CONCLUSIONS: We were able to show that the prevalence of ASB is higher in all patients with diabetes compared with control subjects. We also found that diabetic subjects with ASB more often had albuminuria and symptomatic urinary tract infections.