Melanocortin 4 receptor agonism enhances sexual brain processing in women with hypoactive sexual desire disorder

In addition, MC4R agonism enhanced functional connectivity between the amygdala and the insula during visual erotic stimuli compared with placebo. TRIAL REGISTRATION. ClinicalTrials.gov NCT04179734.

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Bibliographic Details
Published inThe Journal of clinical investigation Vol. 132; no. 19; pp. 1 - 11
Main Authors Thurston, Layla, Hunjan, Tia, Mills, Edouard G, Wall, Matthew B, Ertl, Natalie, Phylactou, Maria, Muzi, Beatrice, Patel, Bijal, Alexander, Emma C, Suladze, Sofiya, Modi, Manish, Eng, Pei C, Bassett, Paul A, Abbara, Ali, Goldmeier, David, Comninos, Alexander N, Dhillo, Waljit S
Format Journal Article
LanguageEnglish
Published Ann Arbor American Society for Clinical Investigation 01.10.2022
Subjects
Agonists
Amygdala
Analysis
Biomedical research
Brain research
Care and treatment
Cerebellum
Clinical Medicine
Cortex (somatosensory)
Diagnosis
Endocrinology
Eroticism
Frigidity (Psychology)
Health aspects
Medical imaging
Medical research
Melanocortin
Melanocortin MC4 receptors
Neural networks
Neuroimaging
Physiology
Placebos
Quantitative psychology
Sexual behavior
Sexual excitement
Sexual health
Supplementary motor area
Visual stimuli
Women
United Kingdom
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More Information
Summary:In addition, MC4R agonism enhanced functional connectivity between the amygdala and the insula during visual erotic stimuli compared with placebo. TRIAL REGISTRATION. ClinicalTrials.gov NCT04179734.
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SourceType-Scholarly Journals-1
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Authorship note: ANC and WSD are co–senior authors.
ISSN:1558-8238
0021-9738
1558-8238
DOI:10.1172/jci152341