Frequent and prolonged administration of glucocorticoid for acute adrenal insufficiency treatment can cause diabetes mellitus: A case of holoprosencephaly

Glucocorticoid (GC)-induced diabetes mellitus (DM) is theoretically unlikely to occur in patients with adrenal insufficiency if adequate physiological replacement doses of GC are given. Herein we report a patient with holoprosencephaly who developed GC-induced DM due to frequent and prolonged admini...

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Published inClinical Pediatric Endocrinology Vol. 28; no. 2; pp. 31 - 36
Main Authors Karashima, Ryoko, Shimada, Aya, Hasegawa, Yukihiro
Format Journal Article
LanguageEnglish
Japanese
Published Japan The Japanese Society for Pediatric Endocrinology 01.01.2019
Subjects
adrenal crisis
Case Report
glucocorticoid-induced diabetes
hydrocortisone
adrenal crisis
hydrocortisone
glucocorticoid-induced diabetes
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Summary:Glucocorticoid (GC)-induced diabetes mellitus (DM) is theoretically unlikely to occur in patients with adrenal insufficiency if adequate physiological replacement doses of GC are given. Herein we report a patient with holoprosencephaly who developed GC-induced DM due to frequent and prolonged administration of high-dose GC for suspected adrenal crisis (AC). GC treatment should be started whenever AC cannot be ruled out. However, the initial and subsequent doses should be adjusted to the severity of AC and to the pace of clinical recovery with treatment, respectively.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0918-5739
1347-7358
DOI:10.1297/cpe.28.31