Long non-coding RNA in stem cell pluripotency and lineage commitment: functions and evolutionary conservation

• Published in: Cellular and molecular life sciences : CMLS Vol. 76; no. 8; pp. 1459 - 1471
• Main Authors: Fico, Annalisa, Fiorenzano, Alessandro, Pascale, Emilia, Patriarca, Eduardo Jorge, Minchiotti, Gabriella
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.04.2019; Springer Nature B.V
• Subjects: Animals; Basic Medicine; Biochemistry; Biological Evolution; Biomedical and Life Sciences; Biomedicine; Cancer and Oncology; Cancer och onkologi; Cell and Molecular Biology; Cell Biology; Cell Differentiation; Cell Lineage; Cell Nucleus - metabolism; Cell- och molekylärbiologi; Chromatin; Clinical Medicine; Compartments; Conservation; Cytoplasm - metabolism; DNA - chemistry; DNA - genetics; DNA - metabolism; Embryonic stem cells; Embryonic Stem Cells - cytology; Embryonic Stem Cells - physiology; Enhancers; Evolutionary conservation; Gene expression; genome; Genome, Human; Genomes; Humans; Klinisk medicin; Life Sciences; LncRNAs; mechanism of action; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; Mice; Non-coding RNA; Pluripotency; Post-transcription; Rats; Regulators; Review; Ribonucleic acid; RNA; RNA, Long Noncoding - chemistry; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Stem cells; T-UCEs; transcription (genetics); Ultraconserved elements; Ultraconserved elements; Embryonic stem cells; T-UCEs; LncRNAs
• ISSN: 1420-682X; 1420-9071; 1420-9071
• DOI: 10.1007/s00018-018-3000-z

LncRNAs have recently emerged as new and fundamental transcriptional and post-transcriptional regulators acting at multiple levels of gene expression. Indeed, lncRNAs participate in a wide variety of stem cell and developmental processes, acting in cis and/or in trans in the nuclear and/or in the cytoplasmic compartments, and generating an intricate network of interactions with RNAs, enhancers, and chromatin-modifier complexes. Given the versatility of these molecules to operate in different subcellular compartments, via different modes of action and with different target specificity, the interest in this research field is rapidly growing. Here, we review recent progress in defining the functional role of lncRNAs in stem cell biology with a specific focus on the underlying mechanisms. We also discuss recent findings on a new family of evolutionary conserved lncRNAs transcribed from ultraconserved elements, which show perfect conservation between human, mouse, and rat genomes, and that are emerging as new player in this complex scenario.