Lysophospholipids in laboratory medicine

Lysophospholipids (LPLs), such as lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P), and lysophosphatidylserine (LysoPS), are attracting attention as second-generation lipid mediators. In our laboratory, the functional roles of these lipid mediators and the mechanisms by which the levels of...

Full description

Saved in:
Bibliographic Details
Published inProceedings of the Japan Academy, Series B Vol. 94; no. 10; pp. 373 - 389
Main Authors YATOMI, Yutaka, KURANO, Makoto, IKEDA, Hitoshi, IGARASHI, Koji, KANO, Kuniyuki, AOKI, Junken
Format Journal Article
LanguageEnglish
Published Japan The Japan Academy 11.12.2018
Subjects
apolipoprotein M
Apolipoproteins
autotaxin
Biomarkers
Blood
Body fluids
Breast cancer
Colorectal cancer
Enzymes
Fibrosis
Gene expression
In vivo methods and tests
Kinases
Laboratories
Laboratory tests
Lipids
Liver
Liver cancer
Lysophosphatidic acid
lysophosphatidylserine
Lysophospholipase
lysophospholipids
Metabolism
Metastasis
Phosphatase
Phosphatidylserine
Phospholipase
Phospholipase A1
Physiology
Proteins
Review
Sphingosine 1-phosphate
apolipoprotein M
lysophosphatidylserine
lysophosphatidic acid
sphingosine 1-phosphate
autotaxin
lysophospholipids
Online AccessGet full text

Cover

More Information
Summary:Lysophospholipids (LPLs), such as lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P), and lysophosphatidylserine (LysoPS), are attracting attention as second-generation lipid mediators. In our laboratory, the functional roles of these lipid mediators and the mechanisms by which the levels of these mediators are regulated in vivo have been studied. Based on these studies, the clinical introduction of assays for LPLs and related proteins has been pursued and will be described in this review. Although assays of these lipids themselves are possible, autotaxin (ATX), apolipoprotein M (ApoM), and phosphatidylserine-specific phospholipase A1 (PS-PLA1) are more promising as alternate biomarkers for LPA, S1P, and LysoPS, respectively. Presently, ATX, which produces LPA through its lysophospholipase D activity, has been shown to be a useful laboratory test for the diagnosis and staging of liver fibrosis, whereas PS-PLA1 and ApoM are considered to be promising clinical markers reflecting the in vivo actions induced by LysoPS and S1P.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
Communicated by Kunihiko SUZUKI, M.J.A.
ISSN:0386-2208
1349-2896
1349-2896
DOI:10.2183/pjab.94.025